Assessment of Structural Intolerance and Durability
General Structure Information 3l81 AP4M1 crystal structure of adaptor protein complex 4 (ap-4) mu4 subunit c- terminal domain, in complex with a sorting peptide from the amyloid precursor protein (app) 1.6Å AUTH P.V.BURGOS,G.A.MARDONES,A.L.ROJAS,L.L.DASILVA,Y.PRABHU,AUTH 2 J.H.HURLEY,J.S.BONIFACINOTITL SORTING OF THE ALZHEIMERS DISEASE AMYLOID PRECURSORTITL 2 PROTEIN MEDIATED BY THE AP-4 COMPLEX.REF DEV.CELL V. 18 425 2010REFN ISSN […]
General Structure Information 3t06 ARHGEF11 crystal structure of the dh/ph fragment of pdzrhogef with n-terminal regulatory elements in complex with human rhoa 2.84Å AUTH J.A.BIELNICKI,A.V.SHKUMATOV,U.DEREWENDA,A.V.SOMLYO,AUTH 2 D.I.SVERGUN,Z.S.DEREWENDATITL INSIGHTS INTO THE MOLECULAR ACTIVATION MECHANISM OF THETITL 2 RHOA-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR, PDZRHOGEF.REF J.BIOL.CHEM. V. 286 35163 2011REFN ISSN 0021-9258PMID 21816819DOI 10.1074/JBC.M111.270918 Variant Set Distributions Ripley’s […]
General Structure Information 4hpf KCNU1 structure of the human slo3 gating ring 3.4Å AUTH M.D.LEONETTI,P.YUAN,Y.HSIUNG,R.MACKINNONTITL FUNCTIONAL AND STRUCTURAL ANALYSIS OF THE HUMAN SLO3 PH- ANDTITL 2 VOLTAGE-GATED K+ CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 109 19274 2012REFN ISSN 0027-8424PMID 23129643DOI 10.1073/PNAS.1215078109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lkn AIP solution structure of the ppiase domain of human aryl-hydrocarbon receptor-interacting protein (aip) -1.0Å AUTH M.LINNERT,Y.J.LIN,A.MANNS,K.HAUPT,A.K.PASCHKE,G.FISCHER,AUTH 2 M.WEIWAD,C.LUECKETITL THE FKBP-TYPE DOMAIN OF THE HUMAN ARYL HYDROCARBONTITL 2 RECEPTOR-INTERACTING PROTEIN REVEALS AN UNUSUAL HSP90TITL 3 INTERACTION.REF BIOCHEMISTRY V. 52 2097 2013REFN ISSN 0006-2960PMID 23418784DOI 10.1021/BI301649M Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bqr DAPK3 crystal structure of human death associated protein kinase 3 (dapk3) in complex with an imidazo-pyridazine ligand 1.75Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,O.FEDOROV,F.NIESEN,A.C.W.PIKE,AUTH 2 E.S.PILKA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3TITL 2 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2csq RIMBP2 solution structure of the second sh3 domain of human rim- binding protein 2 -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OFTITL 2 HUMAN RIM-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4og5 MEN1 human menin with bound inhibitor miv-5 1.63Å AUTH S.HE,T.J.SENTER,J.POLLOCK,C.HAN,S.K.UPADHYAY,T.PUROHIT,AUTH 2 R.D.GOGLIOTTI,C.W.LINDSLEY,T.CIERPICKI,S.R.STAUFFER,AUTH 3 J.GREMBECKATITL HIGH-AFFINITY SMALL-MOLECULE INHIBITORS OF THE MENIN-MIXEDTITL 2 LINEAGE LEUKEMIA (MLL) INTERACTION CLOSELY MIMIC A NATURALTITL 3 PROTEIN-PROTEIN INTERACTION.REF J.MED.CHEM. V. 57 1543 2014REFN ISSN 0022-2623PMID 24472025DOI 10.1021/JM401868D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4gyy OGT crystal structure of human o-glcnac transferase with udp-5sglcnac and a peptide substrate 1.85Å AUTH M.B.LAZARUS,J.JIANG,T.M.GLOSTER,W.F.ZANDBERG,G.E.WHITWORTH,AUTH 2 D.J.VOCADLO,S.WALKERTITL STRUCTURAL SNAPSHOTS OF THE REACTION COORDINATE FOR O-GLCNACTITL 2 TRANSFERASE.REF NAT.CHEM.BIOL. V. 8 966 2012REFN ISSN 1552-4450PMID 23103939DOI 10.1038/NCHEMBIO.1109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4bej DNM1L nucleotide-free dynamin 1-like protein (dnm1l, drp1, dlp1) 3.48Å AUTH C.FROHLICH,S.GRABIGER,D.SCHWEFEL,K.FAELBER,E.ROSENBAUM,AUTH 2 J.MEARS,O.ROCKS,O.DAUMKETITL STRUCTURAL INSIGHTS INTO OLIGOMERIZATION AND MITOCHONDRIALTITL 2 REMODELLING OF DYNAMIN 1-LIKE PROTEIN.REF EMBO J. V. 32 1280 2013REFN ISSN 0261-4189PMID 23584531DOI 10.1038/EMBOJ.2013.74 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4g8a TLR4 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]