Assessment of Structural Intolerance and Durability
General Structure Information 4avx HGS hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1.68 a resolution 1.68Å AUTH E.WILLIAMS,P.CANNING,L.SHRESTHA,T.KROJER,M.VOLLMAR,A.SLOWEY,AUTH 2 S.CONWAY,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE TANDEM VHS AND FYVE DOMAINS OFTITL 2 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASETITL 3 SUBSTRATE (HGS-HRS) BOUND TO AN IP2 COMPOUND AT 1.68 […]
General Structure Information 4j8s CNOT1 crystal structure of human cnot1 mif4g domain in complex with a ttp peptide 1.55Å AUTH M.R.FABIAN,F.FRANK,C.ROUYA,N.SIDDIQUI,W.S.LAI,A.KARETNIKOV,AUTH 2 P.J.BLACKSHEAR,B.NAGAR,N.SONENBERGTITL STRUCTURAL BASIS FOR THE RECRUITMENT OF THE HUMAN CCR4-NOTTITL 2 DEADENYLASE COMPLEX BY TRISTETRAPROLIN.REF NAT.STRUCT.MOL.BIOL. V. 20 735 2013REFN ISSN 1545-9993PMID 23644599DOI 10.1038/NSMB.2572 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2jju SIRPB1 structure of human signal regulatory protein (sirp) beta 1.19Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3gid ACACB the biotin carboxylase (bc) domain of human acetyl-coa carboxylase 2 (acc2) in complex with soraphen a 2.3Å AUTH B.RAYMER,M.KAVANA,A.PRICE,B.WANG,L.CORCORAN,R.KULATHILA,AUTH 2 J.GROARKE,T.MANNTITL SYNTHESIS AND CHARACTERIZATION OF A BODIPY-LABELEDTITL 2 DERIVATIVE OF SORAPHEN A THAT BINDS TO ACETYL-COATITL 3 CARBOXYLASE.REF BIOORG.MED.CHEM.LETT. V. 19 2804 2009REFN ISSN 0960-894XPMID 19359168DOI 10.1016/J.BMCL.2009.03.107 Variant Set Distributions […]
General Structure Information 3t0o RNASET2 crystal structure analysis of human rnase t2 1.59Å AUTH A.THORN,R.STEINFELD,M.ZIEGENBEIN,M.GRAPP,H.H.HSIAO,H.URLAUB,AUTH 2 G.M.SHELDRICK,J.GARTNER,R.KRATZNERTITL STRUCTURE AND ACTIVITY OF THE ONLY HUMAN RNASE T2.REF NUCLEIC ACIDS RES. V. 40 8733 2012REFN ISSN 0305-1048PMID 22735700DOI 10.1093/NAR/GKS614 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1xnj PAPSS1 aps complex of human paps synthetase 1 1.98Å AUTH S.HARJES,P.BAYER,A.J.SCHEIDIGTITL THE CRYSTAL STRUCTURE OF HUMAN PAPS SYNTHETASE 1 REVEALSTITL 2 ASYMMETRY IN SUBSTRATE BINDINGREF J.MOL.BIOL. V. 347 623 2005REFN ISSN 0022-2836PMID 15755455DOI 10.1016/J.JMB.2005.01.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3d8f APBB1 crystal structure of the human fe65-ptb1 domain with bound phosphate (trigonal crystal form) 2.7Å AUTH J.RADZIMANOWSKI,S.RAVAUD,S.SCHLESINGER,J.KOCH,AUTH 2 K.BEYREUTHER,I.SINNING,K.WILDTITL CRYSTAL STRUCTURE OF THE HUMAN FE65-PTB1 DOMAIN.REF J.BIOL.CHEM. V. 283 23113 2008REFN ISSN 0021-9258PMID 18550529DOI 10.1074/JBC.M800861200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sua PLXNB1 crystal structure of the intracellular domain of plexin-b1 in complex with rac1 4.39Å AUTH C.H.BELL,A.R.ARICESCU,E.Y.JONES,C.SIEBOLDTITL A DUAL BINDING MODE FOR RHOGTPASES IN PLEXIN SIGNALLING.REF PLOS BIOL. V. 9 01134 2011REFN ISSN 1544-9173PMID 21912513DOI 10.1371/JOURNAL.PBIO.1001134 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gb8 XPO1 crystal structure of crm1/snurportin-1 complex 2.9Å AUTH X.DONG,A.BISWAS,K.E.SUEL,L.K.JACKSON,R.MARTINEZ,H.GU,AUTH 2 Y.M.CHOOKTITL STRUCTURAL BASIS FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALTITL 2 RECOGNITION BY CRM1.REF NATURE V. 458 1136 2009REFN ISSN 0028-0836PMID 19339969DOI 10.1038/NATURE07975 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wlx ACTN4 solution structure of the third spectrin repeat of alpha- actinin-4 -1.0Å AUTH K.KOWALSKI,A.L.MERKEL,G.W.BOOKERTITL SOLUTION STRUCTURE OF THE THIRD SPECTRIN REPEAT OFTITL 2 ALPHA-ACTININ-4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants