Assessment of Structural Intolerance and Durability
General Structure Information 2cru PDCD5 solution structure of programmed cell death 5 -1.0Å AUTH T.NAGASHIMA,K.IZUMI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF PROGRAMMED CELL DEATH 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qqm NRP1 crystal structure of the a2b1b2 domains from human neuropilin-1 2.0Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1zrh HS3ST1 crystal structure of human heparan sulfate glucosamine 3-o- sulfotransferase 1 in complex with pap 2.1Å AUTH A.DONG,L.DOMBROVSKI,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN HEPARAN SULFATETITL 2 GLUCOSAMINE 3-O-SULFOTRANSFERASE 1 IN COMPLEX WITHTITL 3 PAPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4eyj MAPK13 mapk13 complex with inhibitor 2.1Å AUTH Y.G.ALEVY,A.C.PATEL,A.G.ROMERO,D.A.PATEL,J.TUCKER,AUTH 2 W.T.ROSWIT,C.A.MILLER,R.F.HEIER,D.E.BYERS,T.J.BRETT,AUTH 3 M.J.HOLTZMANTITL IL-13-INDUCED AIRWAY MUCUS PRODUCTION IS ATTENUATED BYTITL 2 MAPK13 INHIBITION.REF J.CLIN.INVEST. V. 122 4555 2012REFN ISSN 0021-9738PMID 23187130DOI 10.1172/JCI64896 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1jbi COCH nmr structure of the lccl domain -1.0Å AUTH E.LIEPINSH,M.TREXLER,A.KAIKKONEN,J.WEIGELT,AUTH 2 L.BANYAI,L.PATTHY,G.OTTINGTITL NMR STRUCTURE OF THE LCCL DOMAIN AND IMPLICATIONSTITL 2 FOR DFNA9 DEAFNESS DISORDER.REF EMBO J. V. 20 5347 2001REFN ISSN 0261-4189PMID 11574466DOI 10.1093/EMBOJ/20.19.5347 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bfx SULT1C2 crystal structure of human sulfotransferase sult1c1 in complex with pap 1.8Å AUTH L.DOMBROVSKI,A.DONG,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURES OF HUMAN SULFOTRANSFERASESTITL 2 SULT1B1 AND SULT1C1 COMPLEXED WITH THE COFACTORTITL 3 PRODUCT ADENOSINE-3-5-DIPHOSPHATE (PAP).REF PROTEINS V. 64 1091 2006REFN ISSN 0887-3585PMID 16804942DOI 10.1002/PROT.21048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2a66 NR5A2 human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter 2.2Å AUTH I.H.SOLOMON,J.M.HAGER,R.SAFI,D.P.MCDONNELL,AUTH 2 M.R.REDINBO,E.A.ORTLUNDTITL CRYSTAL STRUCTURE OF THE HUMAN LRH-1 DBD-DNATITL 2 COMPLEX REVEALS FTZ-F1 DOMAIN POSITIONING ISTITL 3 REQUIRED FOR RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 354 1091 2005REFN ISSN 0022-2836PMID 16289203DOI 10.1016/J.JMB.2005.10.009 Variant […]
General Structure Information 2xue KDM6B crystal structure of jmjd3 2.0Å AUTH L.KRUIDENIER,C.CHUNG,Z.CHENG,J.LIDDLE,K.CHE,G.JOBERTY,AUTH 2 M.BANTSCHEFF,C.BOUNTRA,A.BRIDGES,H.DIALLO,D.EBERHARD,AUTH 3 S.HUTCHINSON,E.JONES,R.KATSO,M.LEVERIDGE,P.K.MANDER,AUTH 4 J.MOSLEY,C.RAMIREZ-MOLINA,P.ROWLAND,C.J.SCHOFIELD,AUTH 5 R.J.SHEPPARD,J.E.SMITH,C.SWALES,R.TANNER,P.THOMAS,A.TUMBER,AUTH 6 G.DREWES,U.OPPERMANN,D.J.PATEL,K.LEE,D.M.WILSONTITL A SELECTIVE JUMONJI H3K27 DEMETHYLASE INHIBITOR MODULATESTITL 2 THE PROINFLAMMATORY MACROPHAGE RESPONSEREF NATURE V. 488 404 2012REFN ISSN 0028-0836PMID 22842901DOI 10.1038/NATURE11262 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ooq PTPRT crystal structure of the human receptor phosphatase ptprt 1.8Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wie RIMBP2 solution structure of the first sh3 domain of kiaa0318 protein -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST SH3 DOMAIN OFTITL 2 KIAA0318 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants