General Structure Information
| PDB ID | 2xue |
| HGNC Gene Label(s) | KDM6B |
| Structure Name | crystal structure of jmjd3 |
| Resolution | 2.0Å |
| Reference | AUTH L.KRUIDENIER,C.CHUNG,Z.CHENG,J.LIDDLE,K.CHE,G.JOBERTY,AUTH 2 M.BANTSCHEFF,C.BOUNTRA,A.BRIDGES,H.DIALLO,D.EBERHARD,AUTH 3 S.HUTCHINSON,E.JONES,R.KATSO,M.LEVERIDGE,P.K.MANDER,AUTH 4 J.MOSLEY,C.RAMIREZ-MOLINA,P.ROWLAND,C.J.SCHOFIELD,AUTH 5 R.J.SHEPPARD,J.E.SMITH,C.SWALES,R.TANNER,P.THOMAS,A.TUMBER,AUTH 6 G.DREWES,U.OPPERMANN,D.J.PATEL,K.LEE,D.M.WILSONTITL A SELECTIVE JUMONJI H3K27 DEMETHYLASE INHIBITOR MODULATESTITL 2 THE PROINFLAMMATORY MACROPHAGE RESPONSEREF NATURE V. 488 404 2012REFN ISSN 0028-0836PMID 22842901DOI 10.1038/NATURE11262 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 427 |
| Number Of SNVs | 37 |
| Number Of Permutations | 24041 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.234 |
| p-value | 0.023 |
COSMIC
| Number Of Residues | 427 |
| Number Of SNVs | 4 |
| Number Of Permutations | 279 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.167 |
| p-value | 0.677 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.416 |
| p-value | 0.555 |