General Structure Information
| PDB ID | 3l81 |
| HGNC Gene Label(s) | AP4M1 |
| Structure Name | crystal structure of adaptor protein complex 4 (ap-4) mu4 subunit c- terminal domain, in complex with a sorting peptide from the amyloid precursor protein (app) |
| Resolution | 1.6Å |
| Reference | AUTH P.V.BURGOS,G.A.MARDONES,A.L.ROJAS,L.L.DASILVA,Y.PRABHU,AUTH 2 J.H.HURLEY,J.S.BONIFACINOTITL SORTING OF THE ALZHEIMERS DISEASE AMYLOID PRECURSORTITL 2 PROTEIN MEDIATED BY THE AP-4 COMPLEX.REF DEV.CELL V. 18 425 2010REFN ISSN 1534-5807PMID 20230749DOI 10.1016/J.DEVCEL.2010.01.015 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 250 |
| Number Of SNVs | 84 |
| Number Of Permutations | 22730 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.031 |
| p-value | 0.305 |
COSMIC
| Number Of Residues | 250 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1356 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.3 |
| p-value | 0.531 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 84 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | -0.236 |
| p-value | 0.556 |