General Structure Information
| PDB ID | 4og5 |
| HGNC Gene Label(s) | MEN1 |
| Structure Name | human menin with bound inhibitor miv-5 |
| Resolution | 1.63Å |
| Reference | AUTH S.HE,T.J.SENTER,J.POLLOCK,C.HAN,S.K.UPADHYAY,T.PUROHIT,AUTH 2 R.D.GOGLIOTTI,C.W.LINDSLEY,T.CIERPICKI,S.R.STAUFFER,AUTH 3 J.GREMBECKATITL HIGH-AFFINITY SMALL-MOLECULE INHIBITORS OF THE MENIN-MIXEDTITL 2 LINEAGE LEUKEMIA (MLL) INTERACTION CLOSELY MIMIC A NATURALTITL 3 PROTEIN-PROTEIN INTERACTION.REF J.MED.CHEM. V. 57 1543 2014REFN ISSN 0022-2623PMID 24472025DOI 10.1021/JM401868D |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 469 |
| Number Of SNVs | 61 |
| Number Of Permutations | 45850 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.008 |
| p-value | 0.6 |
ClinVar
| Number Of Residues | 469 |
| Number Of SNVs | 27 |
| Number Of Permutations | 22273 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.282 |
| p-value | 0.034 |
COSMIC
| Number Of Residues | 469 |
| Number Of SNVs | 14 |
| Number Of Permutations | 10634 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.176 |
| p-value | 0.181 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of ClinVar SNVs | 21 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.128 |
| p-value | 0.042 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 39.0 |
| K Statistic | 0.164 |
| p-value | 0.293 |