Assessment of Structural Intolerance and Durability
General Structure Information 3f6u PROC crystal structure of human activated protein c (apc) complexed with ppack 2.8Å AUTH A.E.SCHMIDT,K.PADMANABHAN,M.C.UNDERWOOD,W.BODE,T.MATHER,AUTH 2 S.P.BAJAJTITL THERMODYNAMIC LINKAGE BETWEEN THE S1 SITE, THE NA+ SITE, ANDTITL 2 THE CA2+ SITE IN THE PROTEASE DOMAIN OF HUMAN ACTIVATEDTITL 3 PROTEIN C (APC).REF J.BIOL.CHEM. V. 277 28987 2002REFN ISSN 0021-9258PMID 12029084DOI 10.1074/JBC.M201892200 […]
General Structure Information 1as4 SERPINA3 cleaved antichymotrypsin a349r 2.1Å AUTH C.M.LUKACS,H.RUBIN,D.W.CHRISTIANSONTITL ENGINEERING AN ANION-BINDING CAVITY INTITL 2 ANTICHYMOTRYPSIN MODULATES THE SPRING-LOADEDTITL 3 SERPIN-PROTEASE INTERACTION.REF BIOCHEMISTRY V. 37 3297 1998REFN ISSN 0006-2960PMID 9521649DOI 10.1021/BI972359E Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lc4 CYP2E1 human cytochrome p450 2e1 in complex with omega-imidazolyl-dodecanoic acid 3.1Å AUTH P.R.PORUBSKY,K.P.BATTAILE,E.E.SCOTTTITL HUMAN CYTOCHROME P450 2E1 STRUCTURES WITH FATTY ACID ANALOGSTITL 2 REVEAL A PREVIOUSLY UNOBSERVED BINDING MODE.REF J.BIOL.CHEM. V. 285 22282 2010REFN ISSN 0021-9258PMID 20463018DOI 10.1074/JBC.M110.109017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2xn5 SERPINA7 crystal structure of thyroxine-binding globulin complexed with furosemide 1.7Å AUTH X.QI,F.LOISEAU,W.L.CHAN,Y.YAN,Z.WEI,L.G.MILROY,AUTH 2 R.M.MYERS,S.V.LEY,R.J.READ,R.W.CARRELL,A.ZHOUTITL ALLOSTERIC MODULATION OF HORMONE RELEASE FROMTITL 2 THYROXINE AND CORTICOSTEROID BINDING-GLOBULINS.REF J.BIOL.CHEM. V. 286 16163 2011REFN ISSN 0021-9258PMID 21325280DOI 10.1074/JBC.M110.171082 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3m7p FN1 fibronectin fragment 2.5Å AUTH M.GRAILLE,M.PAGANO,T.ROSE,M.REBOUD RAVAUX,H.VAN TILBEURGHTITL ZINC INDUCES STRUCTURAL REORGANIZATION OF GELATIN BINDINGTITL 2 DOMAIN FROM HUMAN FIBRONECTIN AND AFFECTS COLLAGEN BINDINGREF STRUCTURE V. 18 710 2010REFN ISSN 0969-2126PMID 20541508DOI 10.1016/J.STR.2010.03.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ije ITGB3 crystal structure of the complete integrin alhavbeta3 ectodomain plus an alpha/beta transmembrane fragment 2.9Å AUTH J.P.XIONG,B.MAHALINGHAM,J.L.ALONSO,L.A.BORRELLI,X.RUI,AUTH 2 S.ANAND,B.T.HYMAN,T.RYSIOK,D.MULLER-POMPALLA,S.L.GOODMAN,AUTH 3 M.A.ARNAOUTTITL CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALPHAVBETA3TITL 2 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT.REF J.CELL BIOL. V. 186 589 2009REFN ISSN 0021-9525PMID 19704023DOI 10.1083/JCB.200905085 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4lpk KRAS crystal structure of k-ras wt, gdp-bound 1.5Å AUTH J.M.OSTREM,U.PETERS,M.L.SOS,J.A.WELLS,K.M.SHOKATTITL K-RAS(G12C) INHIBITORS ALLOSTERICALLY CONTROL GTP AFFINITYTITL 2 AND EFFECTOR INTERACTIONS.REF NATURE V. 503 548 2013REFN ISSN 0028-0836PMID 24256730DOI 10.1038/NATURE12796 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3grs GSR refined structure of glutathione reductase at 1.54 angstroms resolution 1.54Å AUTH P.A.KARPLUS,G.E.SCHULZTITL REFINED STRUCTURE OF GLUTATHIONE REDUCTASE AT 1.54 ATITL 2 RESOLUTION.REF J.MOL.BIOL. V. 195 701 1987REFN ISSN 0022-2836PMID 3656429DOI 10.1016/0022-2836(87)90191-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fzd FGA structure of recombinant alphaec domain from human fibrinogen-420 2.1Å AUTH G.SPRAGGON,D.APPLEGATE,S.J.EVERSE,J.Z.ZHANG,L.VEERAPANDIAN,AUTH 2 C.REDMAN,R.F.DOOLITTLE,G.GRIENINGERTITL CRYSTAL STRUCTURE OF A RECOMBINANT ALPHAEC DOMAIN FROM HUMANTITL 2 FIBRINOGEN-420.REF PROC.NATL.ACAD.SCI.USA V. 95 9099 1998REFN ISSN 0027-8424PMID 9689040DOI 10.1073/PNAS.95.16.9099 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1au1 IFNB1 human interferon-beta crystal structure 2.2Å AUTH M.KARPUSAS,M.NOLTE,C.B.BENTON,W.MEIER,W.N.LIPSCOMB,AUTH 2 S.GOELZTITL THE CRYSTAL STRUCTURE OF HUMAN INTERFERON BETA ATTITL 2 2.2-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 94 11813 1997REFN ISSN 0027-8424PMID 9342320DOI 10.1073/PNAS.94.22.11813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants