Assessment of Structural Intolerance and Durability
General Structure Information 1nb3 CSTA crystal structure of stefin a in complex with cathepsin h: n-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases 2.8Å AUTH S.JENKO,I.DOLENC,G.GUNCAR,A.DOBERSEK,M.PODOBNIK,D.TURKTITL CRYSTAL STRUCTURE OF STEFIN A IN COMPLEX WITH CATHEPSIN H:TITL 2 N-TERMINAL RESIDUES OF INHIBITORS CAN ADAPT TO THE ACTIVETITL 3 SITES OF ENDO- […]
General Structure Information 4iu7 ESR1 crystal structure of the estrogen receptor alpha ligand-binding domain in complex with constrained way-derivative, 2b 2.29Å AUTH S.SRINIVASAN,J.C.NWACHUKWU,A.A.PARENT,V.CAVETT,J.NOWAK,AUTH 2 T.S.HUGHES,D.J.KOJETIN,J.A.KATZENELLENBOGEN,K.W.NETTLESTITL LIGAND BINDING DYNAMICS REWIRE CELLULAR SIGNALING VIATITL 2 ESTROGEN RECEPTOR-ALPHAREF NAT.CHEM.BIOL. V. 9 326 2013REFN ISSN 1552-4450PMID 23524984DOI 10.1038/NCHEMBIO.1214 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3nxp F2 crystal structure of human prethrombin-1 2.2Å AUTH Z.CHEN,L.A.PELC,E.DI CERATITL CRYSTAL STRUCTURE OF PRETHROMBIN-1.REF PROC.NATL.ACAD.SCI.USA V. 107 19278 2010REFN ISSN 0027-8424PMID 20974933DOI 10.1073/PNAS.1010262107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4i8v CYP1A1 human cytochrome p450 1a1 in complex with alpha-naphthoflavone 2.6Å AUTH A.A.WALSH,G.D.SZKLARZ,E.E.SCOTTTITL HUMAN CYTOCHROME P450 1A1 STRUCTURE AND UTILITY INTITL 2 UNDERSTANDING DRUG AND XENOBIOTIC METABOLISM.REF J.BIOL.CHEM. V. 288 12932 2013REFN ISSN 0021-9258PMID 23508959DOI 10.1074/JBC.M113.452953 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1fnf FN1 fragment of human fibronectin encompassing type-iii repeats 7 through 10 2.0Å AUTH D.J.LEAHY,I.AUKHIL,H.P.ERICKSONTITL 2.0 A CRYSTAL STRUCTURE OF A FOUR-DOMAIN SEGMENTTITL 2 OF HUMAN FIBRONECTIN ENCOMPASSING THE RGD LOOP ANDTITL 3 SYNERGY REGION.REF CELL(CAMBRIDGE,MASS.) V. 84 155 1996REFN ISSN 0092-8674PMID 8548820DOI 10.1016/S0092-8674(00)81002-8 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3gt8 EGFR crystal structure of the inactive egfr kinase domain in complex with amp-pnp 2.96Å AUTH N.JURA,N.F.ENDRES,K.ENGEL,S.DEINDL,R.DAS,AUTH 2 M.H.LAMERS,D.E.WEMMER,X.ZHANG,J.KURIYANTITL MECHANISM FOR ACTIVATION OF THE EGF RECEPTORTITL 2 CATALYTIC DOMAIN BY THE JUXTAMEMBRANE SEGMENT.REF CELL(CAMBRIDGE,MASS.) V. 137 1293 2009REFN ISSN 0092-8674PMID 19563760DOI 10.1016/J.CELL.2009.04.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3zqk VWF von willebrand factor a2 domain with calcium 1.7Å AUTH A.J.JAKOBI,A.MASHAGHI,S.J.TANS,E.G.HUIZINGATITL CALCIUM MODULATES FORCE SENSING BY THE VON WILLEBRANDTITL 2 FACTOR A2 DOMAIN.REF NAT.COMMUN. V. 2 385 2011REFN ISSN 2041-1723PMID 21750539DOI 10.1038/NCOMMS1385 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1a9w HBE1 human embryonic gower ii carbonmonoxy hemoglobin 2.9Å AUTH A.J.SUTHERLAND-SMITH,H.M.BAKER,O.M.HOFMANN,AUTH 2 T.BRITTAIN,E.N.BAKERTITL CRYSTAL STRUCTURE OF A HUMAN EMBRYONICTITL 2 HAEMOGLOBIN: THE CARBONMONOXY FORM OF GOWER IITITL 3 (ALPHA2 EPSILON2) HAEMOGLOBIN AT 2.9 A RESOLUTION.REF J.MOL.BIOL. V. 280 475 1998REFN ISSN 0022-2836PMID 9665850DOI 10.1006/JMBI.1998.1868 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1dmw PAH crystal structure of double truncated human phenylalanine hydroxylase with bound 7,8-dihydro-l-biopterin 2.0Å AUTH H.ERLANDSEN,E.BJORGO,T.FLATMARK,R.C.STEVENSTITL CRYSTAL STRUCTURE AND SITE-SPECIFIC MUTAGENESIS OFTITL 2 PTERIN-BOUND HUMAN PHENYLALANINE HYDROXYLASE.REF BIOCHEMISTRY V. 39 2208 2000REFN ISSN 0006-2960PMID 10694386DOI 10.1021/BI992531+ Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j78 GC crystallographic analysis of the human vitamin d binding protein 2.31Å AUTH C.VERBOVEN,A.RABIJNS,M.DE MAEYER,H.VAN BAELEN,AUTH 2 R.BOUILLON,C.DE RANTERTITL A STRUCTURAL BASIS FOR THE UNIQUE BINDING FEATURESTITL 2 OF THE HUMAN VITAMIN D-BINDING PROTEIN.REF NAT.STRUCT.BIOL. V. 9 131 2002REFN ISSN 1072-8368PMID 11799400DOI 10.1038/NSB754 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]