Assessment of Structural Intolerance and Durability
General Structure Information 3a4o LYN lyn kinase domain 3.0Å AUTH N.MIYANO,T.KINOSHITA,R.NAKAI,Y.KIRII,K.YOKOTA,AUTH 2 T.TADATITL STRUCTURAL BASIS FOR THE INHIBITOR RECOGNITION OFTITL 2 HUMAN LYN KINASE DOMAINREF BIOORG.MED.CHEM.LETT. V. 19 6557 2009REFN ISSN 0960-894XPMID 19857964DOI 10.1016/J.BMCL.2009.10.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2arv INHBA structure of human activin a 2.0Å AUTH A.E.HARRINGTON,S.A.MORRIS-TRIGGS,B.T.RUOTOLO,C.V.ROBINSON,AUTH 2 S.OHNUMA,M.HYVONENTITL STRUCTURAL BASIS FOR THE INHIBITION OF ACTIVIN SIGNALLING BYTITL 2 FOLLISTATINREF EMBO J. V. 25 1035 2006REFN ISSN 0261-4189PMID 16482217DOI 10.1038/SJ.EMBOJ.7601000 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gjx HEXB crystallographic structure of human beta-hexosaminidase a 2.8Å AUTH M.J.LEMIEUX,B.L.MARK,M.M.CHERNEY,S.G.WITHERS,D.J.MAHURAN,AUTH 2 M.N.G.JAMESTITL CRYSTALLOGRAPHIC STRUCTURE OF HUMAN BETA-HEXOSAMINIDASE A:TITL 2 INTERPRETATION OF TAY-SACHS MUTATIONS AND LOSS OF GM2TITL 3 GANGLIOSIDE HYDROLYSISREF J.MOL.BIOL. V. 359 913 2006REFN ISSN 0022-2836PMID 16698036DOI 10.1016/J.JMB.2006.04.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2gk1 HEXA x-ray crystal structure of ngt-bound hexa 3.25Å AUTH M.J.LEMIEUX,B.L.MARK,M.M.CHERNEY,S.G.WITHERS,D.J.MAHURAN,AUTH 2 M.N.JAMESTITL CRYSTALLOGRAPHIC STRUCTURE OF HUMAN BETA-HEXOSAMINIDASE A:TITL 2 INTERPRETATION OF TAY-SACHS MUTATIONS AND LOSS OF G(M2)TITL 3 GANGLIOSIDE HYDROLYSIS.REF J.MOL.BIOL. V. 359 913 2006REFN ISSN 0022-2836PMID 16698036DOI 10.1016/J.JMB.2006.04.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1n26 IL6R crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain 2.4Å AUTH J.N.VARGHESE,R.L.MORITZ,M.-Z.LOU,A.VAN DONKELAAR,H.JI,AUTH 2 N.IVANCIC,K.M.BRANSON,N.E.HALL,R.J.SIMPSONTITL STRUCTURE OF THE EXTRACELLULAR DOMAINS OF THE HUMANTITL 2 INTERLEUKIN-6 RECEPTOR ALPHA-CHAIN.REF PROC.NATL.ACAD.SCI.USA V. 99 15959 2002REFN ISSN 0027-8424PMID 12461182DOI 10.1073/PNAS.232432399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4irg ERG uninhibited dna-binding domain of the ets transcription factor erg 1.7Å AUTH M.C.REGAN,P.S.HORANYI,E.E.PRYOR,J.L.SARVER,D.S.CAFISO,AUTH 2 J.H.BUSHWELLERTITL STRUCTURAL AND DYNAMIC STUDIES OF THE TRANSCRIPTION FACTORTITL 2 ERG REVEAL DNA BINDING IS ALLOSTERICALLY AUTOINHIBITED.REF PROC.NATL.ACAD.SCI.USA V. 110 13374 2013REFN ISSN 0027-8424PMID 23898196DOI 10.1073/PNAS.1301726110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1jiq GPI crystal structure of human autocrine motility factor 1.9Å AUTH N.TANAKA,A.HAGA,H.UEMURA,H.AKIYAMA,T.FUNASAKA,AUTH 2 H.NAGASE,A.RAZ,K.T.NAKAMURATITL INHIBITION MECHANISM OF CYTOKINE ACTIVITY OF HUMANTITL 2 AUTOCRINE MOTILITY FACTOR EXAMINED BY CRYSTALTITL 3 STRUCTURE ANALYSES AND SITE-DIRECTED MUTAGENESISTITL 4 STUDIES.REF J.MOL.BIOL. V. 318 985 2002REFN ISSN 0022-2836PMID 12054796DOI 10.1016/S0022-2836(02)00186-9 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3nw6 IGF1R crystal structure of insulin-like growth factor 1 receptor (igf-1r-wt) complex with a carbon-linked proline isostere inhibitor (11a) 2.2Å AUTH A.J.SAMPOGNARO,M.D.WITTMAN,J.M.CARBONI,C.CHANG,A.F.GREER,AUTH 2 W.W.HURLBURT,J.S.SACK,D.M.VYASTITL PROLINE ISOSTERES IN A SERIES OF 2,4-DISUBSTITUTEDTITL 2 PYRROLO[1,2-F][1,2,4]TRIAZINE INHIBITORS OF IGF-1R KINASETITL 3 AND IR KINASE.REF BIOORG.MED.CHEM.LETT. V. 20 5027 2010REFN ISSN 0960-894XPMID 20675137DOI 10.1016/J.BMCL.2010.07.045 Variant Set […]
General Structure Information 3fuk LTA4H leukotriene a4 hydrolase in complex with 1-[2-(1h-indol-5- yloxy)ethyl]piperidine-4-carboxylic acid 1.95Å AUTH D.R.DAVIES,B.MAMAT,O.T.MAGNUSSON,J.CHRISTENSEN,AUTH 2 M.H.HARALDSSON,R.MISHRA,B.PEASE,E.HANSEN,J.SINGH,AUTH 3 D.ZEMBOWER,H.KIM,A.S.KISELYOV,A.B.BURGIN,AUTH 4 M.E.GURNEY,L.J.STEWARTTITL DISCOVERY OF LEUKOTRIENE A4 HYDROLASE INHIBITORSTITL 2 USING METABOLOMICS BIASED FRAGMENT CRYSTALLOGRAPHY.REF J.MED.CHEM. V. 52 4694 2009REFN ISSN 0022-2623PMID 19618939DOI 10.1021/JM900259H Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2x2m RET crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor 2.5Å AUTH L.MOLOGNI,R.ROSTAGNO,S.BRUSSOLO,P.P.KNOWLES,AUTH 2 S.KJAER,J.MURRAY-RUST,E.ROSSO,A.ZAMBON,L.SCAPOZZA,AUTH 3 N.Q.MCDONALD,V.LUCCHINI,C.GAMBACORTI-PASSERINITITL SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP ANDTITL 2 CRYSTALLOGRAPHIC STUDIES OF 3-SUBSTITUTED INDOLIN-TITL 3 2-ONE RET INHIBITORS.REF BIOORG.MED.CHEM. V. 18 1482 2010REFN ISSN 0968-0896PMID 20117004DOI 10.1016/J.BMC.2010.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]