General Structure Information
| PDB ID | 4irg |
| HGNC Gene Label(s) | ERG |
| Structure Name | uninhibited dna-binding domain of the ets transcription factor erg |
| Resolution | 1.7Å |
| Reference | AUTH M.C.REGAN,P.S.HORANYI,E.E.PRYOR,J.L.SARVER,D.S.CAFISO,AUTH 2 J.H.BUSHWELLERTITL STRUCTURAL AND DYNAMIC STUDIES OF THE TRANSCRIPTION FACTORTITL 2 ERG REVEAL DNA BINDING IS ALLOSTERICALLY AUTOINHIBITED.REF PROC.NATL.ACAD.SCI.USA V. 110 13374 2013REFN ISSN 0027-8424PMID 23898196DOI 10.1073/PNAS.1301726110 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 95 |
| Number Of SNVs | 11 |
| Number Of Permutations | 452 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.073 |
| p-value | 0.945 |
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 11 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.47 |
| p-value | 0.416 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
