General Structure Information
| PDB ID | 3a4o |
| HGNC Gene Label(s) | LYN |
| Structure Name | lyn kinase domain |
| Resolution | 3.0Å |
| Reference | AUTH N.MIYANO,T.KINOSHITA,R.NAKAI,Y.KIRII,K.YOKOTA,AUTH 2 T.TADATITL STRUCTURAL BASIS FOR THE INHIBITOR RECOGNITION OFTITL 2 HUMAN LYN KINASE DOMAINREF BIOORG.MED.CHEM.LETT. V. 19 6557 2009REFN ISSN 0960-894XPMID 19857964DOI 10.1016/J.BMCL.2009.10.038 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 259 |
| Number Of SNVs | 27 |
| Number Of Permutations | 3681 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.068 |
| p-value | 0.097 |
COSMIC
| Number Of Residues | 259 |
| Number Of SNVs | 3 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.439 |
| p-value | 0.306 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
