General Structure Information
| PDB ID | 3nw6 |
| HGNC Gene Label(s) | IGF1R |
| Structure Name | crystal structure of insulin-like growth factor 1 receptor (igf-1r-wt) complex with a carbon-linked proline isostere inhibitor (11a) |
| Resolution | 2.2Å |
| Reference | AUTH A.J.SAMPOGNARO,M.D.WITTMAN,J.M.CARBONI,C.CHANG,A.F.GREER,AUTH 2 W.W.HURLBURT,J.S.SACK,D.M.VYASTITL PROLINE ISOSTERES IN A SERIES OF 2,4-DISUBSTITUTEDTITL 2 PYRROLO[1,2-F][1,2,4]TRIAZINE INHIBITORS OF IGF-1R KINASETITL 3 AND IR KINASE.REF BIOORG.MED.CHEM.LETT. V. 20 5027 2010REFN ISSN 0960-894XPMID 20675137DOI 10.1016/J.BMCL.2010.07.045 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 301 |
| Number Of SNVs | 56 |
| Number Of Permutations | 27287 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.252 |
| p-value | 0.392 |
COSMIC
| Number Of Residues | 301 |
| Number Of SNVs | 4 |
| Number Of Permutations | 517 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.167 |
| p-value | 0.584 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.137 |
| p-value | 0.781 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
