Assessment of Structural Intolerance and Durability
General Structure Information 1bhg GUSB human beta-glucuronidase at 2.6 a resolution 2.53Å AUTH S.JAIN,W.B.DRENDEL,Z.W.CHEN,F.S.MATHEWS,W.S.SLY,J.H.GRUBBTITL STRUCTURE OF HUMAN BETA-GLUCURONIDASE REVEALS CANDIDATETITL 2 LYSOSOMAL TARGETING AND ACTIVE-SITE MOTIFS.REF NAT.STRUCT.BIOL. V. 3 375 1996REFN ISSN 1072-8368PMID 8599764DOI 10.1038/NSB0496-375 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1z10 CYP2A6 crystal structure of human microsomal p450 2a6 with coumarin bound 1.9Å AUTH J.K.YANO,M.H.HSU,K.J.GRIFFIN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURES OF HUMAN MICROSOMAL CYTOCHROME P450 2A6 COMPLEXEDTITL 2 WITH COUMARIN AND METHOXSALENREF NAT.STRUCT.MOL.BIOL. V. 12 822 2005REFN ISSN 1545-9993PMID 16086027DOI 10.1038/NSMB971 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1egd ACADM structure of t255e, e376g mutant of human medium chain acyl- coa dehydrogenase 2.4Å AUTH H.J.LEE,M.WANG,R.PASCHKE,A.NANDY,S.GHISLA,J.J.KIMTITL CRYSTAL STRUCTURES OF THE WILD TYPE AND THETITL 2 GLU376GLY/THR255GLU MUTANT OF HUMAN MEDIUM-CHAINTITL 3 ACYL-COA DEHYDROGENASE: INFLUENCE OF THE LOCATIONTITL 4 OF THE CATALYTIC BASE ON SUBSTRATE SPECIFICITY.REF BIOCHEMISTRY V. 35 12412 1996REFN ISSN […]
General Structure Information 1kf9 GHR phage display derived variant of human growth hormone complexed with two copies of the extracellular domain of its receptor 2.6Å AUTH C.A.SCHIFFER,M.ULTSCH,S.WALSH,W.SOMERS,A.M.DE VOS,AUTH 2 A.A.KOSSIAKOFFTITL STRUCTURE OF A PHAGE DISPLAY DERIVED VARIANT OFTITL 2 HUMAN GROWTH HORMONE COMPLEXED TO TWO COPIES OFTITL 3 THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR: EVIDENCETITL […]
General Structure Information 1trn PRSS1 crystal structure of human trypsin 1: unexpected phosphorylation of tyrosine 151 2.2Å AUTH C.GABORIAUD,L.SERRE,O.GUY-CROTTE,E.FOREST,AUTH 2 J.C.FONTECILLA-CAMPSTITL CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTEDTITL 2 PHOSPHORYLATION OF TYR151.REF J.MOL.BIOL. V. 259 995 1996REFN ISSN 0022-2836PMID 8683601DOI 10.1006/JMBI.1996.0376 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3pry HSP90AB1 crystal structure of the middle domain of human hsp90-beta refined at 2.3 a resolution 2.28Å AUTH A.CHAIKUAD,E.PILKA,T.D.SHARPE,C.D.O.COOPER,C.PHILLIPS,AUTH 2 G.BERRIDGE,V.AYINAMPUDI,O.FEDOROV,T.KEATES,AUTH 3 C.THANGARATNARAJAH,T.ZIMMERMANN,M.VOLLMAR,W.W.YUE,K.H.CHE,AUTH 4 T.KROJER,J.R.C.MUNIZ,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 5 J.WEIGELT,A.EDWARDS,A.BULLOCK,AUTH 6 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETATITL 2 REFINED AT 2.3 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 1qki G6PD x-ray structure of human glucose 6-phosphate dehydrogenase (variant canton r459l) complexed with structural nadp+ 3.0Å AUTH S.W.N.AU,S.GOVER,V.M.S.LAM,M.J.ADAMSTITL HUMAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE: THETITL 2 CRYSTAL STRUCTURE REVEALS A STRUCTURAL NADP+TITL 3 MOLECULE AND PROVIDES INSIGHTS INTO ENZYMETITL 4 DEFICIENCYREF STRUCTURE V. 8 293 2000REFN ISSN 0969-2126PMID 10745013DOI 10.1016/S0969-2126(00)00104-0 Variant Set Distributions Ripley’s […]
General Structure Information 3sgj FCGR3A unique carbohydrate-carbohydrate interactions are required for high affinity binding between fcgiii and antibodies lacking core fucose 2.2Å AUTH C.FERRARA,S.GRAU,C.JAGER,P.SONDERMANN,P.BRUNKER,I.WALDHAUER,AUTH 2 M.HENNIG,A.RUF,A.C.RUFER,M.STIHLE,P.UMANA,J.BENZTITL UNIQUE CARBOHYDRATE-CARBOHYDRATE INTERACTIONS ARE REQUIREDTITL 2 FOR HIGH AFFINITY BINDING BETWEEN FCGAMMARIII AND ANTIBODIESTITL 3 LACKING CORE FUCOSE.REF PROC.NATL.ACAD.SCI.USA V. 108 12669 2011REFN ISSN 0027-8424PMID 21768335DOI 10.1073/PNAS.1108455108 Variant Set […]
General Structure Information 3o8y ALOX5 stable-5-lipoxygenase 2.39Å AUTH N.C.GILBERT,S.G.BARTLETT,M.T.WAIGHT,D.B.NEAU,W.E.BOEGLIN,AUTH 2 A.R.BRASH,M.E.NEWCOMERTITL THE STRUCTURE OF HUMAN 5-LIPOXYGENASE.REF SCIENCE V. 331 217 2011REFN ISSN 0036-8075PMID 21233389DOI 10.1126/SCIENCE.1197203 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c0o HCK src family kinase hck with bound inhibitor a-770041 2.85Å AUTH A.BURCHAT,D.W.BORHANI,D.J.CALDERWOOD,G.C.HIRST,B.LI,AUTH 2 R.F.STACHLEWITZTITL DISCOVERY OF A-770041, A SRC-FAMILY SELECTIVE ORALLY ACTIVETITL 2 LCK INHIBITOR THAT PREVENTS ORGAN ALLOGRAFT REJECTION.REF BIOORG.MED.CHEM.LETT. V. 16 118 2006REFN ISSN 0960-894XPMID 16216497DOI 10.1016/J.BMCL.2005.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]