General Structure Information
| PDB ID | 1trn |
| HGNC Gene Label(s) | PRSS1 |
| Structure Name | crystal structure of human trypsin 1: unexpected phosphorylation of tyrosine 151 |
| Resolution | 2.2Å |
| Reference | AUTH C.GABORIAUD,L.SERRE,O.GUY-CROTTE,E.FOREST,AUTH 2 J.C.FONTECILLA-CAMPSTITL CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTEDTITL 2 PHOSPHORYLATION OF TYR151.REF J.MOL.BIOL. V. 259 995 1996REFN ISSN 0022-2836PMID 8683601DOI 10.1006/JMBI.1996.0376 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 220 |
| Number Of SNVs | 43 |
| Number Of Permutations | 3726 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.028 |
| p-value | 0.829 |
ClinVar
| Number Of Residues | 220 |
| Number Of SNVs | 9 |
| Number Of Permutations | 749 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.0 |
| p-value | 0.234 |
COSMIC
| Number Of Residues | 220 |
| Number Of SNVs | 23 |
| Number Of Permutations | 17399 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.016 |
| p-value | 0.797 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of ClinVar SNVs | 9 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | -0.065 |
| p-value | 0.312 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 21 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.068 |
| p-value | 0.84 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
