General Structure Information
| PDB ID | 3pry |
| HGNC Gene Label(s) | HSP90AB1 |
| Structure Name | crystal structure of the middle domain of human hsp90-beta refined at 2.3 a resolution |
| Resolution | 2.28Å |
| Reference | AUTH A.CHAIKUAD,E.PILKA,T.D.SHARPE,C.D.O.COOPER,C.PHILLIPS,AUTH 2 G.BERRIDGE,V.AYINAMPUDI,O.FEDOROV,T.KEATES,AUTH 3 C.THANGARATNARAJAH,T.ZIMMERMANN,M.VOLLMAR,W.W.YUE,K.H.CHE,AUTH 4 T.KROJER,J.R.C.MUNIZ,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 5 J.WEIGELT,A.EDWARDS,A.BULLOCK,AUTH 6 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETATITL 2 REFINED AT 2.3 A RESOLUTIONREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 252 |
| Number Of SNVs | 46 |
| Number Of Permutations | 9534 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.107 |
| p-value | 0.115 |
COSMIC
| Number Of Residues | 252 |
| Number Of SNVs | 3 |
| Number Of Permutations | 138 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.667 |
| p-value | 0.307 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.439 |
| p-value | 0.211 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
