General Structure Information
| PDB ID | 3sgj |
| HGNC Gene Label(s) | FCGR3A |
| Structure Name | unique carbohydrate-carbohydrate interactions are required for high affinity binding between fcgiii and antibodies lacking core fucose |
| Resolution | 2.2Å |
| Reference | AUTH C.FERRARA,S.GRAU,C.JAGER,P.SONDERMANN,P.BRUNKER,I.WALDHAUER,AUTH 2 M.HENNIG,A.RUF,A.C.RUFER,M.STIHLE,P.UMANA,J.BENZTITL UNIQUE CARBOHYDRATE-CARBOHYDRATE INTERACTIONS ARE REQUIREDTITL 2 FOR HIGH AFFINITY BINDING BETWEEN FCGAMMARIII AND ANTIBODIESTITL 3 LACKING CORE FUCOSE.REF PROC.NATL.ACAD.SCI.USA V. 108 12669 2011REFN ISSN 0027-8424PMID 21768335DOI 10.1073/PNAS.1108455108 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 169 |
| Number Of SNVs | 36 |
| Number Of Permutations | 4995 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.057 |
| p-value | 0.86 |
COSMIC
| Number Of Residues | 169 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4538 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.036 |
| p-value | 0.537 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 36 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.313 |
| p-value | 0.159 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
