General Structure Information
| PDB ID | 1kf9 |
| HGNC Gene Label(s) | GHR |
| Structure Name | phage display derived variant of human growth hormone complexed with two copies of the extracellular domain of its receptor |
| Resolution | 2.6Å |
| Reference | AUTH C.A.SCHIFFER,M.ULTSCH,S.WALSH,W.SOMERS,A.M.DE VOS,AUTH 2 A.A.KOSSIAKOFFTITL STRUCTURE OF A PHAGE DISPLAY DERIVED VARIANT OFTITL 2 HUMAN GROWTH HORMONE COMPLEXED TO TWO COPIES OFTITL 3 THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR: EVIDENCETITL 4 FOR STRONG STRUCTURAL COUPLING BETWEEN RECEPTORTITL 5 BINDING SITESREF J.MOL.BIOL. V. 316 277 2002REFN ISSN 0022-2836PMID 11851338DOI 10.1006/JMBI.2001.5348 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 175 |
| Number Of SNVs | 46 |
| Number Of Permutations | 10743 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.02 |
| p-value | 0.943 |
ClinVar
| Number Of Residues | 175 |
| Number Of SNVs | 11 |
| Number Of Permutations | 2366 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.109 |
| p-value | 0.291 |
COSMIC
| Number Of Residues | 175 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1140 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.3 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of ClinVar SNVs | 11 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.052 |
| p-value | 0.296 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.137 |
| p-value | 0.764 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
