Assessment of Structural Intolerance and Durability
General Structure Information 3qmk APLP1 crystal structure of the e2 domain of aplp1 in complex with heparin hexasaccharide 2.21Å AUTH Y.XUE,S.LEE,Y.HATITL CRYSTAL STRUCTURE OF AMYLOID PRECURSOR-LIKE PROTEIN 1 ANDTITL 2 HEPARIN COMPLEX SUGGESTS A DUAL ROLE OF HEPARIN IN E2TITL 3 DIMERIZATION.REF PROC.NATL.ACAD.SCI.USA V. 108 16229 2011REFN ISSN 0027-8424PMID 21930949DOI 10.1073/PNAS.1103407108 Variant Set Distributions Ripley’s […]
General Structure Information 3t1i MRE11A crystal structure of human mre11: understanding tumorigenic mutations 3.0Å AUTH Y.B.PARK,J.CHAE,Y.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN MRE11: UNDERSTANDING TUMORIGENICTITL 2 MUTATIONSREF STRUCTURE V. 19 1591 2011REFN ISSN 0969-2126PMID 22078559DOI 10.1016/J.STR.2011.09.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h11 TPMT amino-terminal truncated thiopurine s-methyltransferase complexed with s-adenosyl-l-homocysteine 1.89Å AUTH J.R.HORTON,X.CHENGTITL AMINO-TERMINAL TRUNCATED THIOPURINETITL 2 S-METHYLTRANSFERASE COMPLEXED WITHTITL 3 S-ADENOSYL-L-HOMOCYSTEINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1mzd GZMK crystal structure of human pro-granzyme k 2.9Å AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,E.WILHARM,AUTH 2 P.FUENTES-PRIOR,W.KLINKERT,W.BODE,D.E.JENNETITL THE 2.2-A CRYSTAL STRUCTURE OF HUMAN PRO-GRANZYMETITL 2 K REVEALS A RIGID ZYMOGEN WITH UNUSUAL FEATURESREF J.BIOL.CHEM. V. 277 50923 2002REFN ISSN 0021-9258PMID 12384499DOI 10.1074/JBC.M207962200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4kbc CSNK1D ck1d in complex with {4-[3-(4-fluorophenyl)-1h-pyrazol-4-yl]pyridin-2- yl}methanol inhibitor 1.98Å AUTH S.MENTE,E.ARNOLD,T.BUTLER,S.CHAKRAPANI,R.CHANDRASEKARAN,AUTH 2 K.CHERRY,K.DIRICO,A.DORAN,K.FISHER,P.GALATSIS,M.GREEN,AUTH 3 M.HAYWARD,J.HUMPHREY,J.KNAFELS,J.LI,S.LIU,M.MARCONI,AUTH 4 S.MCDONALD,J.OHREN,V.PARADIS,B.SNEED,K.WALTON,T.WAGERTITL LIGAND-PROTEIN INTERACTIONS OF SELECTIVE CASEIN KINASE 1TITL 2 DELTA INHIBITORS.REF J.MED.CHEM. V. 56 6819 2013REFN ISSN 0022-2623PMID 23919824DOI 10.1021/JM4006324 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qxi KLK7 high resolution structure of human kallikrein 7 in complex with suc-ala-ala-pro-phe-chloromethylketone 1.0Å AUTH M.DEBELA,P.HESS,V.MAGDOLEN,N.M.SCHECHTER,T.STEINER,AUTH 2 R.HUBER,W.BODE,P.GOETTIGTITL CHYMOTRYPTIC SPECIFICITY DETERMINANTS IN THE 1.0 ATITL 2 STRUCTURE OF THE ZINC-INHIBITED HUMAN TISSUETITL 3 KALLIKREIN 7.REF PROC.NATL.ACAD.SCI.USA V. 104 16086 2007REFN ISSN 0027-8424PMID 17909180DOI 10.1073/PNAS.0707811104 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3e37 FNTA protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5 1.8Å AUTH M.A.HAST,S.FLETCHER,C.G.CUMMINGS,E.E.PUSATERI,AUTH 2 M.A.BLASKOVICH,K.RIVAS,M.H.GELB,W.C.VAN VOORHIS,AUTH 3 S.M.SEBTI,A.D.HAMILTON,L.S.BEESETITL STRUCTURAL BASIS FOR BINDING AND SELECTIVITY OFTITL 2 ANTIMALARIAL AND ANTICANCER ETHYLENEDIAMINETITL 3 INHIBITORS TO PROTEIN FARNESYLTRANSFERASE.REF CHEM.BIOL. V. 16 181 2009REFN ISSN 1074-5521PMID 19246009DOI 10.1016/J.CHEMBIOL.2009.01.014 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2aot HNMT histamine methyltransferase complexed with the antihistamine drug diphenhydramine 1.9Å AUTH J.R.HORTON,K.SAWADA,M.NISHIBORI,X.CHENGTITL STRUCTURAL BASIS FOR INHIBITION OF HISTAMINETITL 2 N-METHYLTRANSFERASE BY DIVERSE DRUGSREF J.MOL.BIOL. V. 353 334 2005REFN ISSN 0022-2836PMID 16168438DOI 10.1016/J.JMB.2005.08.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d5r TOB1 crystal structure of a tob-hcaf1 complex 2.5Å AUTH M.HORIUCHI,K.TAKEUCHI,N.NODA,N.MUROYA,T.SUZUKI,AUTH 2 T.NAKAMURA,J.KAWAMURA-TSUZUKU,K.TAKAHASI,AUTH 3 T.YAMAMOTO,F.INAGAKITITL STRUCTURAL BASIS FOR THE ANTIPROLIFERATIVE ACTIVITYTITL 2 OF THE TOB-HCAF1 COMPLEX.REF J.BIOL.CHEM. V. 284 13244 2009REFN ISSN 0021-9258PMID 19276069DOI 10.1074/JBC.M809250200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pff ACLY truncated human atp-citrate lyase with adp and tartrate bound 2.3Å AUTH T.SUN,K.HAYAKAWA,M.E.FRASERTITL ADP-MG2+ BOUND TO THE ATP-GRASP DOMAIN OF ATP-CITRATE LYASE.REF ACTA CRYSTALLOGR.,SECT.F V. 67 1168 2011REFN ESSN 1744-3091PMID 22102020DOI 10.1107/S1744309111028363 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants