Assessment of Structural Intolerance and Durability
General Structure Information 2zks GZMM structural insights into the proteolytic machinery of apoptosis- inducing granzyme m 2.7Å AUTH L.WU,L.WANG,G.HUA,K.LIU,X.YANG,Y.ZHAI,M.BARTLAM,F.SUN,Z.FANTITL STRUCTURAL BASIS FOR PROTEOLYTIC SPECIFICITY OF THE HUMANTITL 2 APOPTOSIS-INDUCING GRANZYME MREF J.IMMUNOL. V. 183 421 2009REFN ISSN 0022-1767PMID 19542453DOI 10.4049/JIMMUNOL.0803088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1nst NDST1 the sulfotransferase domain of human haparin sulfate n- deacetylase/n-sulfotransferase 2.3Å AUTH Y.KAKUTA,T.SUEYOSHI,M.NEGISHI,L.C.PEDERSENTITL CRYSTAL STRUCTURE OF THE SULFOTRANSFERASE DOMAINTITL 2 OF HUMAN HEPARAN SULFATE N-DEACETYLASE/TITL 3 N-SULFOTRANSFERASE 1.REF J.BIOL.CHEM. V. 274 10673 1999REFN ISSN 0021-9258PMID 10196134DOI 10.1074/JBC.274.16.10673 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4ja8 IDH2 complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor 1.55Å AUTH F.WANG,J.TRAVINS,B.DELABARRE,V.PENARD-LACRONIQUE,S.SCHALM,AUTH 2 E.HANSEN,K.STRALEY,A.KERNYTSKY,W.LIU,C.GLISER,H.YANG,AUTH 3 S.GROSS,E.ARTIN,V.SAADA,E.MYLONAS,C.QUIVORON,AUTH 4 J.POPOVICI-MULLER,J.O.SAUNDERS,F.G.SALITURO,S.YAN,S.MURRAY,AUTH 5 W.WEI,Y.GAO,L.DANG,M.DORSCH,S.AGRESTA,D.P.SCHENKEIN,AUTH 6 S.A.BILLER,S.M.SU,S.DE BOTTON,K.E.YENTITL TARGETED INHIBITION OF MUTANT IDH2 IN LEUKEMIA CELLS INDUCESTITL 2 CELLULAR DIFFERENTIATION.REF SCIENCE V. 340 622 2013REFN ISSN 0036-8075PMID 23558173DOI 10.1126/SCIENCE.1234769 Variant Set Distributions Ripley’s K […]
General Structure Information 2ob4 CDC34 human ubiquitin-conjugating enzyme cdc34 2.4Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1z57 CLK1 crystal structure of human clk1 in complex with 10z-hymenialdisine 1.7Å AUTH A.N.BULLOCK,S.DAS,J.E.DEBRECZENI,P.RELLOS,O.FEDOROV,AUTH 2 F.H.NIESEN,K.GUO,E.PAPAGRIGORIOU,A.L.AMOS,S.CHO,B.E.TURK,AUTH 3 G.GHOSH,S.KNAPPTITL KINASE DOMAIN INSERTIONS DEFINE DISTINCT ROLES OF CLKTITL 2 KINASES IN SR PROTEIN PHOSPHORYLATION.REF STRUCTURE V. 17 352 2009REFN ISSN 0969-2126PMID 19278650DOI 10.1016/J.STR.2008.12.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1wsv AMT crystal structure of human t-protein of glycine cleavage system 2.6Å AUTH K.OKAMURA-IKEDA,H.HOSAKA,M.YOSHIMURA,E.YAMASHITA,AUTH 2 S.TOMA,A.NAKAGAWA,K.FUJIWARA,Y.MOTOKAWA,H.TANIGUCHITITL CRYSTAL STRUCTURE OF HUMAN T-PROTEIN OF GLYCINETITL 2 CLEAVAGE SYSTEM AT 2.0A RESOLUTION AND ITSTITL 3 IMPLICATION FOR UNDERSTANDING NON-KETOTICTITL 4 HYPERGLYCINEMIAREF J.MOL.BIOL. V. 351 1146 2005REFN ISSN 0022-2836PMID 16051266DOI 10.1016/J.JMB.2005.06.056 Variant Set Distributions Ripley’s K […]
General Structure Information 1s9c HSD17B4 crystal structure analysis of the 2-enoyl-coa hydratase 2 domain of human peroxisomal multifunctional enzyme type 2 3.0Å AUTH M.K.KOSKI,A.M.HAAPALAINEN,J.K.HILTUNENTITL CRYSTAL STRUCTURE OF 2-ENOYL-COA HYDRATASE 2 FROMTITL 2 HUMAN PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2.REF J.MOL.BIOL. V. 345 1157 2005REFN ISSN 0022-2836PMID 15644212DOI 10.1016/J.JMB.2004.11.009 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1zbq HSD17B4 crystal structure of human 17-beta-hydroxysteroid dehydrogenase type 4 in complex with nad 2.71Å AUTH P.LUKACIK,N.SHAFQAT,K.KAVANAGH,J.BRAY,F.VON DELFT,A.EDWARDS,AUTH 2 C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE 4 IN COMPLEX WITH NADREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pf6 BCAM lutheran glycoprotein, n-terminal domains 1 and 2 2.2Å AUTH T.J.MANKELOW,N.BURTON,F.O.STEFANSDOTTIR,F.A.SPRING,AUTH 2 S.F.PARSONS,J.S.PEDERSEN,C.L.OLIVEIRA,D.LAMMIE,T.WESS,AUTH 3 N.MOHANDAS,J.A.CHASIS,R.L.BRADY,D.J.ANSTEETITL THE LAMININ 511/521-BINDING SITE ON THE LUTHERAN BLOOD GROUPTITL 2 GLYCOPROTEIN IS LOCATED AT THE FLEXIBLE JUNCTION OF IGTITL 3 DOMAINS 2 AND 3.REF BLOOD V. 110 3398 2007REFN ISSN 0006-4971PMID 17638854DOI 10.1182/BLOOD-2007-06-094748 Variant Set Distributions […]
General Structure Information 2h5g ALDH18A1 crystal structure of human pyrroline-5-carboxylate synthetase 2.25Å AUTH E.PAPAGRIGORIOU,N.SHAFQAT,A.P.TURNBULL,G.BERRIDGE,V.HOZJAN,AUTH 2 K.KAVANAGH,O.GILEADI,C.SMEE,J.BRAY,F.GORREC,M.SUNDSTROM,AUTH 3 C.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATETITL 2 SYNTHETASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants