General Structure Information
| PDB ID | 3qmk |
| HGNC Gene Label(s) | APLP1 |
| Structure Name | crystal structure of the e2 domain of aplp1 in complex with heparin hexasaccharide |
| Resolution | 2.21Å |
| Reference | AUTH Y.XUE,S.LEE,Y.HATITL CRYSTAL STRUCTURE OF AMYLOID PRECURSOR-LIKE PROTEIN 1 ANDTITL 2 HEPARIN COMPLEX SUGGESTS A DUAL ROLE OF HEPARIN IN E2TITL 3 DIMERIZATION.REF PROC.NATL.ACAD.SCI.USA V. 108 16229 2011REFN ISSN 0027-8424PMID 21930949DOI 10.1073/PNAS.1103407108 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 195 |
| Number Of SNVs | 55 |
| Number Of Permutations | 19405 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.074 |
| p-value | 0.474 |
COSMIC
| Number Of Residues | 195 |
| Number Of SNVs | 8 |
| Number Of Permutations | 8403 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.214 |
| p-value | 0.61 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.155 |
| p-value | 0.428 |