General Structure Information
| PDB ID | 3e37 |
| HGNC Gene Label(s) | FNTA |
| Structure Name | protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5 |
| Resolution | 1.8Å |
| Reference | AUTH M.A.HAST,S.FLETCHER,C.G.CUMMINGS,E.E.PUSATERI,AUTH 2 M.A.BLASKOVICH,K.RIVAS,M.H.GELB,W.C.VAN VOORHIS,AUTH 3 S.M.SEBTI,A.D.HAMILTON,L.S.BEESETITL STRUCTURAL BASIS FOR BINDING AND SELECTIVITY OFTITL 2 ANTIMALARIAL AND ANTICANCER ETHYLENEDIAMINETITL 3 INHIBITORS TO PROTEIN FARNESYLTRANSFERASE.REF CHEM.BIOL. V. 16 181 2009REFN ISSN 1074-5521PMID 19246009DOI 10.1016/J.CHEMBIOL.2009.01.014 |
Variant Set Distributions
ExAC Variants
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.398 |
| p-value | 0.343 |