Assessment of Structural Intolerance and Durability
General Structure Information 3ajb PEX3 crystal structure of human pex3p in complex with n-terminal pex19p peptide 2.5Å AUTH Y.SATO,H.SHIBATA,T.NAKATSU,H.NAKANO,Y.KASHIWAYAMA,T.IMANAKA,AUTH 2 H.KATOTITL STRUCTURAL BASIS FOR DOCKING OF PEROXISOMAL MEMBRANE PROTEINTITL 2 CARRIER PEX19P ONTO ITS RECEPTOR PEX3PREF EMBO J. V. 29 4083 2010REFN ISSN 0261-4189PMID 21102411DOI 10.1038/EMBOJ.2010.293 Variant Set Distributions Mapped Variants
General Structure Information 2a5g ARF6 cholera toxin a1 subunit bound to arf6(q67l) 2.66Å AUTH C.J.ONEAL,M.G.JOBLING,R.K.HOLMES,W.G.HOLTITL STRUCTURAL BASIS FOR THE ACTIVATION OF CHOLERA TOXIN BYTITL 2 HUMAN ARF6-GTP.REF SCIENCE V. 309 1093 2005REFN ISSN 0036-8075PMID 16099990DOI 10.1126/SCIENCE.1113398 Variant Set Distributions Mapped Variants
General Structure Information 1bi8 CDK6 mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1bi8 CDKN2D mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Mapped Variants
General Structure Information 2j1k CXADR cav-2 fibre head in complex with car d1 2.3Å AUTH E.SEIRADAKE,H.LORTAT-JACOB,O.BILLET,E.J.KREMER,S.CUSACKTITL STRUCTURAL AND MUTATIONAL ANALYSIS OF HUMAN AD37 AND CANINETITL 2 ADENOVIRUS 2 FIBER HEADS IN COMPLEX WITH THE D1 DOMAIN OFTITL 3 COXSACKIE AND ADENOVIRUS RECEPTOR.REF J.BIOL.CHEM. V. 281 33704 2006REFN ISSN 0021-9258PMID 16923808DOI 10.1074/JBC.M605316200 Variant Set Distributions Mapped […]
General Structure Information 2i6a ADK human adenosine kinase in complex with 5-deoxy-5- iodotubercidin 2.2Å AUTH S.W.MUCHMORE,R.A.SMITH,A.O.STEWART,M.D.COWART,AUTH 2 A.GOMTSYAN,M.A.MATULENKO,H.YU,J.M.SEVERIN,AUTH 3 S.S.BHAGWAT,C.H.LEE,E.A.KOWALUK,M.F.JARVIS,AUTH 4 C.L.JAKOBTITL CRYSTAL STRUCTURES OF HUMAN ADENOSINE KINASETITL 2 INHIBITOR COMPLEXES REVEAL TWO DISTINCT BINDINGTITL 3 MODES.REF J.MED.CHEM. V. 49 6726 2006REFN ISSN 0022-2623PMID 17154503DOI 10.1021/JM060189A Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2p6b PPP3R1 crystal structure of human calcineurin in complex with pvivit peptide 2.3Å AUTH H.LI,L.ZHANG,A.RAO,S.C.HARRISON,P.G.HOGANTITL STRUCTURE OF CALCINEURIN IN COMPLEX WITH PVIVITTITL 2 PEPTIDE: PORTRAIT OF A LOW-AFFINITY SIGNALLINGTITL 3 INTERACTIONREF J.MOL.BIOL. V. 369 1296 2007REFN ISSN 0022-2836PMID 17498738DOI 10.1016/J.JMB.2007.04.032 Variant Set Distributions Mapped Variants
General Structure Information 2a8h ADAM17 crystal structure of catalytic domain of tace with thiomorpholine sulfonamide hydroxamate inhibitor 2.3Å AUTH J.I.LEVIN,J.M.CHEN,L.M.LAAKSO,M.DU,J.SCHMID,W.XU,AUTH 2 T.CUMMONS,J.XU,G.JIN,D.BARONE,J.S.SKOTNICKITITL ACETYLENIC TACE INHIBITORS. PART 3: THIOMORPHOLINETITL 2 SULFONAMIDE HYDROXAMATES.REF BIOORG.MED.CHEM.LETT. V. 16 1605 2006REFN ISSN 0960-894XPMID 16426848DOI 10.1016/J.BMCL.2005.12.020 Variant Set Distributions Mapped Variants
General Structure Information 1vjb ESRRG crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4- hydroxytamoxifen 3.2Å AUTH H.GRESCHIK,R.FLAIG,J.P.RENAUD,D.MORASTITL STRUCTURAL BASIS FOR THE DEACTIVATION OF THETITL 2 ESTROGEN-RELATED RECEPTOR {GAMMA} BYTITL 3 DIETHYLSTILBESTROL OR 4-HYDROXYTAMOXIFEN ANDTITL 4 DETERMINANTS OF SELECTIVITY.REF J.BIOL.CHEM. V. 279 33639 2004REFN ISSN 0021-9258PMID 15161930DOI 10.1074/JBC.M402195200 Variant […]
General Structure Information 1nkp MAX crystal structure of myc-max recognizing dna 1.8Å AUTH S.K.NAIR,S.K.BURLEYTITL X-RAY STRUCTURES OF MYC-MAX AND MAD-MAXTITL 2 RECOGNIZING DNA: MOLECULAR BASES OF REGULATION BYTITL 3 PROTO-ONCOGENIC TRANSCRIPTION FACTORSREF CELL(CAMBRIDGE,MASS.) V. 112 193 2003REFN ISSN 0092-8674PMID 12553908DOI 10.1016/S0092-8674(02)01284-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]