General Structure Information
| PDB ID | 1bi8 |
| HGNC Gene Label(s) | CDK6 |
| Structure Name | mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex |
| Resolution | 2.8Å |
| Reference | AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 264 |
| Number Of SNVs | 34 |
| Number Of Permutations | 17644 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.187 |
| p-value | 0.1 |
COSMIC
| Number Of Residues | 264 |
| Number Of SNVs | 3 |
| Number Of Permutations | 157 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.464 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.267 |
| p-value | 0.63 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
