General Structure Information
| PDB ID | 2i6a |
| HGNC Gene Label(s) | ADK |
| Structure Name | human adenosine kinase in complex with 5-deoxy-5- iodotubercidin |
| Resolution | 2.2Å |
| Reference | AUTH S.W.MUCHMORE,R.A.SMITH,A.O.STEWART,M.D.COWART,AUTH 2 A.GOMTSYAN,M.A.MATULENKO,H.YU,J.M.SEVERIN,AUTH 3 S.S.BHAGWAT,C.H.LEE,E.A.KOWALUK,M.F.JARVIS,AUTH 4 C.L.JAKOBTITL CRYSTAL STRUCTURES OF HUMAN ADENOSINE KINASETITL 2 INHIBITOR COMPLEXES REVEAL TWO DISTINCT BINDINGTITL 3 MODES.REF J.MED.CHEM. V. 49 6726 2006REFN ISSN 0022-2623PMID 17154503DOI 10.1021/JM060189A |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 341 |
| Number Of SNVs | 64 |
| Number Of Permutations | 34634 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.101 |
| p-value | 0.71 |
ClinVar
| Number Of Residues | 341 |
| Number Of SNVs | 4 |
| Number Of Permutations | 838 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.667 |
| p-value | 0.953 |
COSMIC
| Number Of Residues | 341 |
| Number Of SNVs | 4 |
| Number Of Permutations | 16 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.167 |
| p-value | 0.487 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 64 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.356 |
| p-value | 0.894 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 64 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | -0.41 |
| p-value | 0.126 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
