Assessment of Structural Intolerance and Durability
General Structure Information 2fdb FGF8 crystal structure of fibroblast growth factor (fgf)8b in complex with fgf receptor (fgfr) 2c 2.28Å AUTH S.K.OLSEN,J.Y.H.LI,C.BROMLEIGH,A.V.ELISEENKOVA,AUTH 2 O.A.IBRAHIMI,Z.LAO,F.ZHANG,R.J.LINHARDT,A.L.JOYNER,AUTH 3 M.MOHAMMADITITL STRUCTURAL BASIS BY WHICH ALTERNATIVE SPLICINGTITL 2 MODULATES THE ORGANIZER ACTIVITY OF FGF8 IN THETITL 3 BRAINREF GENES DEV. V. 20 185 2006REFN ISSN 0890-9369PMID 16384934DOI 10.1101/GAD.1365406 Variant Set […]
General Structure Information 1syx TXNL4A the crystal structure of a binary u5 snrnp complex 2.35Å AUTH T.K.NIELSEN,S.LIU,R.LUHRMANN,R.FICNERTITL STRUCTURAL BASIS FOR THE BIFUNCTIONALITY OF THE U5 SNRNP 52KTITL 2 PROTEIN (CD2BP2).REF J.MOL.BIOL. V. 369 902 2007REFN ISSN 0022-2836PMID 17467737DOI 10.1016/J.JMB.2007.03.077 Variant Set Distributions Mapped Variants
General Structure Information 3sqv UBE2L3 crystal structure of e. coli o157:h7 e3 ubiquitin ligase, nlel, with a human e2, ubch7 3.3Å AUTH D.Y.LIN,J.DIAO,J.CHENTITL CRYSTAL STRUCTURES OF TWO BACTERIAL HECT-LIKE E3 LIGASES INTITL 2 COMPLEX WITH A HUMAN E2 REVEAL ATOMIC DETAILS OFTITL 3 PATHOGEN-HOST INTERACTIONS.REF PROC.NATL.ACAD.SCI.USA V. 109 1925 2012REFN ISSN 0027-8424PMID 22308380DOI 10.1073/PNAS.1115025109 Variant […]
General Structure Information 3ygs CASP9 apaf-1 card in complex with prodomain of procaspase-9 2.5Å AUTH H.QIN,S.M.SRINIVASULA,G.WU,T.FERNANDES-ALNEMRI,AUTH 2 E.S.ALNEMRI,Y.SHITITL STRUCTURAL BASIS OF PROCASPASE-9 RECRUITMENT BYTITL 2 THE APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.REF NATURE V. 399 549 1999REFN ISSN 0028-0836PMID 10376594DOI 10.1038/21124 Variant Set Distributions Mapped Variants
General Structure Information 1mhd SMAD3 crystal structure of a smad mh1 domain bound to dna 2.8Å AUTH Y.SHI,Y.F.WANG,L.JAYARAMAN,H.YANG,J.MASSAGUE,AUTH 2 N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TOTITL 2 DNA: INSIGHTS ON DNA BINDING IN TGF-BETA SIGNALING.REF CELL(CAMBRIDGE,MASS.) V. 94 585 1998REFN ISSN 0092-8674PMID 9741623DOI 10.1016/S0092-8674(00)81600-1 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bpn IL13RA1 crystal structure of the il4-il4r-il13ra ternary complex 3.02Å AUTH S.L.LAPORTE,Z.S.JUO,J.VACLAVIKOVA,L.A.COLF,X.QI,N.M.HELLER,AUTH 2 A.D.KEEGAN,K.C.GARCIATITL MOLECULAR AND STRUCTURAL BASIS OF CYTOKINE RECEPTORTITL 2 PLEIOTROPY IN THE INTERLEUKIN-4/13 SYSTEM.REF CELL(CAMBRIDGE,MASS.) V. 132 259 2008REFN ISSN 0092-8674PMID 18243101DOI 10.1016/J.CELL.2007.12.030 Variant Set Distributions Mapped Variants
General Structure Information 4ie2 ARG2 crystal structure of human arginase-2 complexed with inhibitor 1h 2.21Å AUTH A.GOLEBIOWSKI,R.PAUL BECKETT,M.VAN ZANDT,M.K.JI,AUTH 2 D.WHITEHOUSE,T.R.RYDER,E.JAGDMANN,M.ANDREOLI,A.MAZUR,AUTH 3 M.PADMANILAYAM,A.COUSIDO-SIAH,A.MITSCHLER,F.X.RUIZ,AUTH 4 A.PODJARNY,H.SCHROETERTITL 2-SUBSTITUTED-2-AMINO-6-BORONOHEXANOIC ACIDS AS ARGINASETITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 2027 2013REFN ISSN 0960-894XPMID 23453840DOI 10.1016/J.BMCL.2013.02.024 Variant Set Distributions Mapped Variants
General Structure Information 1u7f SMAD3 crystal structure of the phosphorylated smad3/smad4 heterotrimeric complex 2.6Å AUTH B.M.CHACKO,B.Y.QIN,A.TIWARI,G.SHI,S.LAM,AUTH 2 L.J.HAYWARD,M.DE CAESTECKER,K.LINTITL STRUCTURAL BASIS OF HETEROMERIC SMAD PROTEINTITL 2 ASSEMBLY IN TGF-BETA SIGNALINGREF MOL.CELL V. 15 813 2004REFN ISSN 1097-2765PMID 15350224DOI 10.1016/J.MOLCEL.2004.07.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1foe RAC1 crystal structure of rac1 in complex with the guanine nucleotide exchange region of tiam1 2.8Å AUTH D.K.WORTHYLAKE,K.L.ROSSMAN,J.SONDEKTITL CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THETITL 2 GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1.REF NATURE V. 408 682 2000REFN ISSN 0028-0836PMID 11130063DOI 10.1038/35047014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2xns GNAI1 crystal structure of human g alpha i1 bound to a designed helical peptide derived from the goloco motif of rgs14 3.41Å AUTH D.W.SAMMOND,D.E.BOSCH,G.L.BUTTERFOSS,C.PURBECK,AUTH 2 M.MACHIUS,D.P.SIDEROVSKI,B.KUHLMANTITL COMPUTATIONAL DESIGN OF THE SEQUENCE AND STRUCTURETITL 2 OF A PROTEIN-BINDING PEPTIDE.REF J.AM.CHEM.SOC. V. 133 4190 2011REFN ISSN 0002-7863PMID 21388199DOI 10.1021/JA110296Z Variant Set Distributions Ripley’s […]