General Structure Information
| PDB ID | 2xns |
| HGNC Gene Label(s) | GNAI1 |
| Structure Name | crystal structure of human g alpha i1 bound to a designed helical peptide derived from the goloco motif of rgs14 |
| Resolution | 3.41Å |
| Reference | AUTH D.W.SAMMOND,D.E.BOSCH,G.L.BUTTERFOSS,C.PURBECK,AUTH 2 M.MACHIUS,D.P.SIDEROVSKI,B.KUHLMANTITL COMPUTATIONAL DESIGN OF THE SEQUENCE AND STRUCTURETITL 2 OF A PROTEIN-BINDING PEPTIDE.REF J.AM.CHEM.SOC. V. 133 4190 2011REFN ISSN 0002-7863PMID 21388199DOI 10.1021/JA110296Z |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 316 |
| Number Of SNVs | 45 |
| Number Of Permutations | 23853 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.218 |
| p-value | 0.081 |
COSMIC
| Number Of Residues | 316 |
| Number Of SNVs | 8 |
| Number Of Permutations | 5971 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.214 |
| p-value | 0.176 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 45 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | -0.265 |
| p-value | 0.072 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
