General Structure Information
| PDB ID | 1mhd |
| HGNC Gene Label(s) | SMAD3 |
| Structure Name | crystal structure of a smad mh1 domain bound to dna |
| Resolution | 2.8Å |
| Reference | AUTH Y.SHI,Y.F.WANG,L.JAYARAMAN,H.YANG,J.MASSAGUE,AUTH 2 N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TOTITL 2 DNA: INSIGHTS ON DNA BINDING IN TGF-BETA SIGNALING.REF CELL(CAMBRIDGE,MASS.) V. 94 585 1998REFN ISSN 0092-8674PMID 9741623DOI 10.1016/S0092-8674(00)81600-1 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 123 |
| Number Of SNVs | 14 |
| Number Of Permutations | 926 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.165 |
| p-value | 0.734 |
ClinVar
| Number Of Residues | 123 |
| Number Of SNVs | 3 |
| Number Of Permutations | 75 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.699 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 14 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.223 |
| p-value | 0.614 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
