Assessment of Structural Intolerance and Durability
General Structure Information 3i4r NUP107 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Mapped Variants
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dpr VLDLR human rhinovirus 2 bound to a concatamer of the vldl receptor module v3 3.5Å AUTH J.QUEROL-AUDI,T.KONECSNI,J.POUS,O.CARUGO,I.FITA,N.VERDAGUER,AUTH 2 D.BLAASTITL MINOR GROUP HUMAN RHINOVIRUS-RECEPTOR INTERACTIONS: GEOMETRYTITL 2 OF MULTIMODULAR ATTACHMENT AND BASIS OF RECOGNITIONREF FEBS LETT. V. 583 235 2009REFN ISSN 0014-5793PMID 19073182DOI 10.1016/J.FEBSLET.2008.12.014 Variant Set Distributions Mapped Variants
General Structure Information 4lcj CTBP2 ctbp2 in complex with substrate mtob 2.86Å AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3zke DYNLL1 structure of lc8 in complex with nek9 peptide 2.2Å AUTH P.GALLEGO,A.VELAZQUEZ-CAMPOY,L.REGUE,J.ROIG,D.REVERTERTITL STRUCTURAL ANALYSIS OF THE REGULATION OF THE DYNLL/LC8TITL 2 BINDING TO NEK9 BY PHOSPHORYLATIONREF J.BIOL.CHEM. V. 288 12283 2013REFN ISSN 0021-9258PMID 23482567DOI 10.1074/JBC.M113.459149 Variant Set Distributions Mapped Variants
General Structure Information 2bsk TIMM10 crystal structure of the tim9 tim10 hexameric complex 3.3Å AUTH C.T.WEBB,M.A.GORMAN,M.LAZAROU,M.T.RYAN,J.M.GULBISTITL CRYSTAL STRUCTURE OF THE MITOCHONDRIAL CHAPERONETITL 2 TIM9*10 REVEALS A SIX-BLADED ALPHA-PROPELLER.REF MOL.CELL V. 21 123 2006REFN ISSN 1097-2765PMID 16387659DOI 10.1016/J.MOLCEL.2005.11.010 Variant Set Distributions Mapped Variants
General Structure Information 3k9p UBE2K the crystal structure of e2-25k and ubiquitin complex 2.8Å AUTH S.KO,G.B.KANG,S.M.SONG,J.-G.LEE,D.Y.SHIN,J.-H.YUN,Y.SHENG,AUTH 2 C.CHEONG,Y.H.JEON,Y.-K.JUNG,C.H.ARROWSMITH,G.V.AVVAKUMOV,AUTH 3 S.DHE-PAGANON,Y.J.YOO,S.H.EOM,W.LEETITL STRUCTURAL BASIS OF E2-25K/UBB+1 INTERACTION LEADING TOTITL 2 PROTEASOME INHIBITION AND NEUROTOXICITYREF J.BIOL.CHEM. V. 285 36070 2010REFN ISSN 0021-9258PMID 20826778DOI 10.1074/JBC.M110.145219 Variant Set Distributions Mapped Variants
General Structure Information 1tzn ANTXR2 crystal structure of the anthrax toxin protective antigen heptameric prepore bound to the vwa domain of cmg2, an anthrax toxin receptor 4.3Å AUTH D.B.LACY,D.J.WIGELSWORTH,R.A.MELNYK,S.C.HARRISON,R.J.COLLIERTITL STRUCTURE OF HEPTAMERIC PROTECTIVE ANTIGEN BOUND TO ANTITL 2 ANTHRAX TOXIN RECEPTOR: A ROLE FOR RECEPTOR IN PH-DEPENDENTTITL 3 PORE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 101 13147 2004REFN […]
General Structure Information 3phw RPS27A otu domain of crimean congo hemorrhagic fever virus in complex with ubiquitin 2.0Å AUTH M.AKUTSU,Y.YE,S.VIRDEE,J.W.CHIN,D.KOMANDERTITL MOLECULAR BASIS FOR UBIQUITIN AND ISG15 CROSS-REACTIVITY INTITL 2 VIRAL OVARIAN TUMOR DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 108 2228 2011REFN ISSN 0027-8424PMID 21266548DOI 10.1073/PNAS.1015287108 Variant Set Distributions Mapped Variants
General Structure Information 3rk2 SNAP25 truncated snare complex 2.2Å AUTH D.KUMMEL,S.S.KRISHNAKUMAR,D.T.RADOFF,F.LI,C.G.GIRAUDO,AUTH 2 F.PINCET,J.E.ROTHMAN,K.M.REINISCHTITL COMPLEXIN CROSS-LINKS PREFUSION SNARES INTO A ZIGZAG ARRAY.REF NAT.STRUCT.MOL.BIOL. V. 18 927 2011REFN ISSN 1545-9993PMID 21785414DOI 10.1038/NSMB.2101 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants