Assessment of Structural Intolerance and Durability
General Structure Information 1k93 CALM3 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1k93 CALM2 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1k93 CALM1 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1a3q NFKB2 human nf-kappa-b p52 bound to dna 2.1Å AUTH P.CRAMER,C.J.LARSON,G.L.VERDINE,C.W.MULLERTITL STRUCTURE OF THE HUMAN NF-KAPPAB P52 HOMODIMER-DNATITL 2 COMPLEX AT 2.1 A RESOLUTION.REF EMBO J. V. 16 7078 1997REFN ISSN 0261-4189PMID 9384586DOI 10.1093/EMBOJ/16.23.7078 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hb4 RAN crystal structure of crm1 inhibitor leptomycin b in complex with crm1(537dltvk541/glceq)-ran-ranbp1 2.05Å AUTH Q.SUN,Y.P.CARRASCO,Y.HU,X.GUO,H.MIRZAEI,J.MACMILLAN,AUTH 2 Y.M.CHOOKTITL NUCLEAR EXPORT INHIBITION THROUGH COVALENT CONJUGATION ANDTITL 2 HYDROLYSIS OF LEPTOMYCIN B BY CRM1.REF PROC.NATL.ACAD.SCI.USA V. 110 1303 2013REFN ISSN 0027-8424PMID 23297231DOI 10.1073/PNAS.1217203110 Variant Set Distributions Mapped Variants
General Structure Information 2of5 CRADD oligomeric death domain complex 3.2Å AUTH H.H.PARK,E.LOGETTE,S.RAUNSER,S.CUENIN,T.WALZ,J.TSCHOPP,H.WUTITL DEATH DOMAIN ASSEMBLY MECHANISM REVEALED BY CRYSTALTITL 2 STRUCTURE OF THE OLIGOMERIC PIDDOSOME CORE COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 128 533 2007REFN ISSN 0092-8674PMID 17289572DOI 10.1016/J.CELL.2007.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bg0 SEC13 architecture of a coat for the nuclear pore membrane 3.15Å AUTH K.C.HSIA,P.STAVROPOULOS,G.BLOBEL,A.HOELZTITL ARCHITECTURE OF A COAT FOR THE NUCLEAR PORETITL 2 MEMBRANE.REF CELL(CAMBRIDGE,MASS.) V. 131 1313 2007REFN ISSN 0092-8674PMID 18160040DOI 10.1016/J.CELL.2007.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fju PLCB2 activated rac1 bound to its effector phospholipase c beta 2 2.2Å AUTH M.R.JEZYK,J.T.SNYDER,S.GERSHBERG,D.K.WORTHYLAKE,AUTH 2 T.K.HARDEN,J.SONDEKTITL CRYSTAL STRUCTURE OF RAC1 BOUND TO ITS EFFECTORTITL 2 PHOSPHOLIPASE C-BETA2.REF NAT.STRUCT.MOL.BIOL. V. 13 1135 2006REFN ISSN 1545-9993PMID 17115053DOI 10.1038/NSMB1175 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4f52 RBX1 structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants
General Structure Information 4nod TFAM distinct structural features of tfam drive mitochondrial dna packaging versus transcriptional activation 2.9Å AUTH H.B.NGO,G.A.LOVELY,R.PHILLIPS,D.C.CHANTITL DISTINCT STRUCTURAL FEATURES OF TFAM DRIVE MITOCHONDRIAL DNATITL 2 PACKAGING VERSUS TRANSCRIPTIONAL ACTIVATION.REF NAT COMMUN V. 5 3077 2014REFN ESSN 2041-1723PMID 24435062DOI 10.1038/NCOMMS4077 Variant Set Distributions Mapped Variants