Assessment of Structural Intolerance and Durability
General Structure Information 2eoc PARP3 solution structure of the wgr domain from human poly [adp- ribose] polymerase-3 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE WGR DOMAIN FROM HUMANTITL 2 POLY [ADP-RIBOSE] POLYMERASE-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1go4 MAD1L1 crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20. 2.05Å AUTH L.SIRONI,M.MAPELLI,S.KNAPP,A.ANTONI,K.T.JEANG,AUTH 2 A.MUSACCHIOTITL CRYSTAL STRUCTURE OF THE TETRAMERIC MAD1-MAD2 CORETITL 2 COMPLEX: IMPLICATIONS OF A SAFETY BELT BINDINGTITL 3 MECHANISM FOR THE SPINDLE CHECKPOINTREF EMBO J. V. 21 2496 2002REFN ISSN 0261-4189PMID 12006501DOI 10.1093/EMBOJ/21.10.2496 […]
General Structure Information 2df3 SIGLEC7 the structure of siglec-7 in complex with alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl 1.9Å AUTH H.ATTRILL,H.TAKAZAWA,S.WITT,S.KELM,R.ISECKE,R.BROSSMER,AUTH 2 T.ANDO,H.ISHIDA,M.KISO,P.R.CROCKER,D.M.F.VAN AALTENTITL THE STRUCTURE OF SIGLEC-7 IN COMPLEX WITH SIALOSIDES: LEADSTITL 2 FOR RATIONAL STRUCTURE-BASED INHIBITOR DESIGNREF BIOCHEM.J. V. 397 271 2006REFN ISSN 0264-6021PMID 16623661DOI 10.1042/BJ20060103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3bin EPB41L3 structure of the dal-1 and tslc1 (372-383) complex 2.3Å AUTH R.D.BUSAM,A.-G.THORSELL,A.FLORES,M.HAMMARSTROM,C.PERSSON,AUTH 2 B.OBRINK,B.M.HALLBERGTITL STRUCTURAL BASIS OF TUMOR SUPPRESSOR IN LUNG CANCER 1TITL 2 (TSLC1) BINDING TO DIFFERENTIALLY EXPRESSED INTITL 3 ADENOCARCINOMA OF THE LUNG (DAL-1/4.1B)REF J.BIOL.CHEM. V. 286 4511 2011REFN ISSN 0021-9258PMID 21131357DOI 10.1074/JBC.M110.174011 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3hd6 RHCG crystal structure of the human rhesus glycoprotein rhcg 2.1Å AUTH F.GRUSWITZ,S.CHAUDHARY,J.D.HO,A.SCHLESSINGER,B.PEZESHKI,AUTH 2 C.M.HO,A.SALI,C.M.WESTHOFF,R.M.STROUDTITL FUNCTION OF HUMAN RH BASED ON STRUCTURE OF RHCG AT 2.1 A.REF PROC.NATL.ACAD.SCI.USA V. 107 9638 2010REFN ISSN 0027-8424PMID 20457942DOI 10.1073/PNAS.1003587107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3g5c ADAM22 structural and biochemical studies on the ectodomain of human adam22 2.36Å AUTH H.LIU,A.SHIM,X.CHEN,X.HETITL STRUCTURAL AND BIOCHEMICAL STUDIES ON THE ECTODOMAIN OFTITL 2 HUMAN ADAM22REF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bn3 ICAM5 crystal structure of icam-5 in complex with al i domain 2.1Å AUTH H.ZHANG,J.M.CASASNOVAS,M.JIN,J.H.LIU,C.G.GAHMBERG,AUTH 2 T.A.SPRINGER,J.-H.WANGTITL AN UNUSUAL ALLOSTERIC MOBILITY OF THE C-TERMINAL HELIX OF ATITL 2 HIGH-AFFINITY ALPHA L INTEGRIN I DOMAIN VARIANT BOUND TOTITL 3 ICAM-5REF MOL.CELL V. 31 432 2008REFN ISSN 1097-2765PMID 18691975DOI 10.1016/J.MOLCEL.2008.06.022 Variant Set Distributions Mapped […]
General Structure Information 3abd MAD2L2 structure of human rev7 in complex with a human rev3 fragment in a monoclinic crystal 1.9Å AUTH K.HARA,H.HASHIMOTO,Y.MURAKUMO,S.KOBAYASHI,T.KOGAME,S.UNZAI,AUTH 2 S.AKASHI,S.TAKEDA,T.SHIMIZU,M.SATOTITL CRYSTAL STRUCTURE OF HUMAN REV7 IN COMPLEX WITH A HUMAN REV3TITL 2 FRAGMENT AND STRUCTURAL IMPLICATION OF THE INTERACTIONTITL 3 BETWEEN DNA POLYMERASE {ZETA} AND REV1REF J.BIOL.CHEM. V. 285 12299 […]
General Structure Information 2osg TJP2 solution structure and binding property of the domain- swapped dimer of zo2pdz2 -1.0Å AUTH J.W.WU,Y.S.YANG,J.H.ZHANG,P.JI,W.J.DU,P.JIANG,AUTH 2 D.H.XIE,H.D.HUANG,M.WU,G.Z.ZHANG,J.H.WU,Y.Y.SHITITL DOMAIN-SWAPPED DIMERIZATION OF THE SECOND PDZTITL 2 DOMAIN OF ZO2 MAY PROVIDE A STRUCTURAL BASIS FORTITL 3 THE POLYMERIZATION OF CLAUDINSREF J.BIOL.CHEM. V. 282 35988 2007REFN ISSN 0021-9258PMID 17897942DOI 10.1074/JBC.M703826200 Variant Set Distributions […]
General Structure Information 2kdg MYOT solution structure of the 1st ig domain of myotilin -1.0Å AUTH O.HEIKKINEN,P.PERMI,H.KOSKELA,O.CARPEN,J.YLANNE,AUTH 2 I.KILPELAINENTITL SOLUTION STRUCTURE OF THE FIRST IMMUNOGLOBULINTITL 2 DOMAIN OF HUMAN MYOTILINREF J.BIOMOL.NMR V. 44 107 2009REFN ISSN 0925-2738PMID 19418025DOI 10.1007/S10858-009-9320-4 Variant Set Distributions Mapped Variants