3G5C.B | ADAM22

General Structure Information

PDB ID	3g5c
HGNC Gene Label(s)	ADAM22
Structure Name	structural and biochemical studies on the ectodomain of human adam22
Resolution	2.36Å
Reference	AUTH H.LIU,A.SHIM,X.CHEN,X.HETITL STRUCTURAL AND BIOCHEMICAL STUDIES ON THE ECTODOMAIN OFTITL 2 HUMAN ADAM22REF J.BIOL.CHEM. 2009REFN ESSN 1083-351X

Variant Set Distributions

ExAC Variants

Number Of Residues	486
Number Of SNVs	90
Number Of Permutations	50360
Optimal Distance Threshold	9.0
K Statistic	0.022
p-value	0.42

COSMIC

Number Of Residues	486
Number Of SNVs	9
Number Of Permutations	6423
Optimal Distance Threshold	12.0
K Statistic	0.028
p-value	0.753

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	90
Number Of COSMIC SNVs	8
Optimal Distance Threshold	34.0
K Statistic	0.151
p-value	0.645

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
7:87757951		T>I	B:238	(69.69, 3.88, 23.01)
7:87757970		M>I	B:244	(64.17, 8.63, 3.72)
7:87759715	rs201144493 COSM3641968 COSM3641966 COSM3641967	R>W	B:256	(71.83, 28.18, -7.54)
7:87759724	rs558399747 COSM1092697 COSM1154859 COSM1092696	V>I	B:259	(72.65, 17.19, -5.73)
7:87759727	COSM308875 COSM308876	V>I	B:260	(76.25, 18.29, -3.26)
7:87759733	rs376692654	T>A	B:262	(70.76, 19.49, -1.34)
7:87759740		T>S	B:264	(75.24, 18.40, 2.49)
7:87759746	rs369078128	A>V	B:266	(70.00, 17.76, 5.02)
7:87759763		M>V	B:272	(71.29, 20.34, 14.38)
7:87760585		I>R	B:276	(68.03, 17.99, 20.22)
7:87760593		D>Y	B:279	(71.33, 14.37, 25.25)
7:87760614		V>I	B:286	(70.27, 7.58, 11.74)
7:87760627	rs369521709	M>T	B:290	(68.44, 11.36, 0.91)
7:87760639	rs545692266 COSM2156853 COSM2156851 COSM2156852	A>V	B:294	(66.04, 17.47, -9.87)
7:87760659		I>V	B:301	(53.28, 20.84, -2.84)
7:87760686		R>C	B:310	(46.40, 13.16, 2.22)
7:87760687		R>H	B:310	(46.40, 13.16, 2.22)
7:87760741		H>P	B:328	(60.16, 13.05, 7.43)
7:87760743		L>F	B:329	(58.96, 16.25, 2.55)
7:87762183		G>R	B:332	(60.74, 24.83, -0.26)
7:87762195		E>K	B:336	(48.63, 28.45, 4.58)
7:87762204	rs371111786	R>W	B:339	(51.56, 24.13, 13.23)
7:87762205	COSM3641980 COSM3641978 COSM3641979	R>Q	B:339	(51.56, 24.13, 13.23)
7:87762210	COSM22802 COSM308874	G>R	B:341	(54.34, 20.98, 10.10)
7:87762213		A>T	B:342	(52.96, 17.57, 9.44)
7:87762225		G>C	B:346	(52.29, 7.43, 16.21)
7:87762258	COSM3778652 COSM3778650 COSM3778651	V>M	B:357	(55.70, 17.68, 6.05)
7:87763646		F>L	B:360	(63.46, 26.47, 3.46)
7:87763666		A>V	B:367	(65.88, 21.09, 13.16)
7:87763698		I>L	B:378	(58.07, 9.21, 18.91)
7:87763704		I>V	B:380	(55.96, 13.68, 21.79)
7:87763724	rs181713252	K>N	B:386	(48.31, 18.41, 31.63)
7:87763726		L>S	B:387	(49.09, 23.19, 28.31)
7:87763728		A>T	B:388	(45.03, 24.74, 30.07)
7:87765309	COSM273876 COSM273877	E>K	B:395	(60.77, 24.03, 33.73)
7:87765312		D>N	B:396	(64.22, 25.52, 30.92)
7:87765316	COSM3883108 COSM3883106 COSM3883107	T>M	B:397	(62.49, 29.96, 28.66)
7:87765328		C>Y	B:401	(59.87, 24.50, 24.60)
7:87765330		I>V	B:402	(60.49, 22.05, 20.97)
7:87765337		G>E	B:404	(56.02, 25.12, 21.94)
7:87772358		K>R	B:413	(65.38, 22.16, 26.03)
7:87772376		I>T	B:419	(60.38, 12.98, 28.52)
7:87772403		S>I	B:428	(52.36, 1.01, 24.81)
7:87772415	rs370119404	A>V	B:432	(59.78, -1.56, 17.69)
7:87774474	rs370077891	I>T	B:452	(80.07, -0.67, 14.06)
7:87774507	rs372937043	P>L	B:463	(86.95, 8.57, 24.92)
7:87774734		C>F	B:466	(84.49, 4.20, 26.53)
7:87774751		E>Q	B:472	(88.87, -3.13, 29.22)
7:87774770	COSM354611 COSM354610	T>I	B:478	(90.44, -3.17, 17.11)
7:87774778		Q>E	B:481	(93.40, -11.69, 23.25)
7:87774782		D>G	B:482	(90.56, -12.01, 25.85)
7:87774793		S>G	B:486	(82.78, -3.61, 23.42)
7:87774794		S>T	B:486	(82.78, -3.61, 23.42)
7:87774816		K>N	B:493	(83.59, -9.41, 31.44)
7:87774822		K>N	B:495	(83.89, -11.85, 26.94)
7:87778297		Q>H	B:497	(75.58, -12.85, 27.53)
7:87778303		M>I	B:499	(71.67, -18.86, 23.18)
7:87778317	COSM747695 COSM1150765 COSM747694	R>Q	B:504	(64.35, -6.13, 24.72)
7:87778333	rs200566855	D>E	B:509	(49.55, -8.35, 26.62)
7:87778340		I>V	B:512	(57.59, -10.93, 21.90)
7:87778344	rs200398630	R>L	B:513	(61.15, -12.90, 26.74)
7:87778350		T>M	B:515	(66.78, -13.63, 23.57)
7:87778371		Q>R	B:522	(72.79, -5.55, 18.81)
7:87780302	rs199684808	P>T	B:525	(65.59, -7.27, 16.51)
7:87780578		C>R	B:542	(47.05, -6.29, 19.15)
7:87780606		D>A	B:551	(39.39, 2.41, 29.08)
7:87780607		D>E	B:551	(39.39, 2.41, 29.08)
7:87780620		Y>H	B:556	(45.11, 9.12, 22.97)
7:87782544		A>T	B:564	(34.90, 3.65, 30.05)
7:87782582		E>D	B:576	(18.71, 7.12, 21.09)
7:87782620		T>K	B:589	(21.00, 13.66, 10.14)
7:87782640	rs368940210	R>W	B:596	(23.39, -6.64, 15.21)
7:87785230		T>A	B:606	(32.78, 8.24, 32.60)
7:87785240		G>D	B:609	(35.99, 16.77, 30.08)
7:87785243		N>S	B:610	(36.33, 20.82, 28.68)
7:87785254	rs557229466	L>F	B:614	(44.59, 15.02, 21.19)
7:87785266	rs376104896	D>N	B:618	(33.66, 20.21, 16.91)
7:87785284		T>A	B:624	(23.15, 11.09, 29.24)
7:87785299		Q>E	B:629	(18.40, -2.92, 38.07)
7:87785303	rs201832352	G>E	B:630	(20.61, 0.87, 40.88)
7:87785316		N>K	B:634	(27.84, 9.47, 33.57)
7:87792334	rs374179429	H>N	B:639	(32.57, 15.11, 18.35)
7:87792341		K>T	B:641	(38.07, 16.90, 14.47)
7:87792343	rs368127471	L>F	B:642	(43.42, 15.24, 14.33)
7:87792353	rs189398829	D>V	B:645	(38.94, 13.24, 7.12)
7:87792376	rs182178671	D>N	B:653	(38.83, 1.00, 13.16)
7:87792383	rs374307477	T>I	B:655	(38.01, -2.20, 18.87)
7:87792412		E>K	B:665	(33.08, 1.93, 8.13)
7:87792419	rs368308668	R>K	B:667	(30.23, -2.46, 9.73)
7:87792478		I>V	B:687	(49.12, -20.05, 15.49)
7:87792479		I>T	B:687	(49.12, -20.05, 15.49)
7:87795185		H>Q	B:705	(62.73, -27.78, 23.94)
7:87795207	rs199870639	T>S	B:713	(60.59, -29.80, 14.67)
7:87795210		Y>D	B:714	(60.69, -31.84, 20.67)
7:87795223	rs192156761	N>S	B:718	(69.42, -29.74, 27.74)

3G5C.B | ADAM22.

3G5C.B | ADAM22

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
7:87759716	COSM3032935	R>Q	B:256	(71.83, 28.18, -7.54)
7:87760639	COSM2156853	A>V	B:294	(66.04, 17.47, -9.87)
7:87760697	COSM747703	M>I	B:313	(52.91, 8.79, 3.22)
7:87762210	COSM22802	G>R	B:341	(54.34, 20.98, 10.10)
7:87762211	COSM1452620	G>V	B:341	(54.34, 20.98, 10.10)
7:87763647	COSM217418	G>W	B:361	(64.78, 27.01, 6.35)
7:87774474	COSM3032995	I>T	B:452	(80.07, -0.67, 14.06)
7:87774488	COSM1721440	E>K	B:457	(86.82, -4.89, 14.55)
7:87774730	COSM1755394	E>K	B:465	(80.83, 7.79, 26.14)
7:87778343	COSM1313374	R>C	B:513	(61.15, -12.90, 26.74)