Assessment of Structural Intolerance and Durability
General Structure Information 3k72 ITGAX structure of integrin alphax beta2 3.7Å AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kex ERBB3 crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (her3) 2.8Å AUTH N.JURA,Y.SHAN,X.CAO,D.E.SHAW,J.KURIYANTITL STRUCTURAL ANALYSIS OF THE CATALYTICALLY INACTIVETITL 2 KINASE DOMAIN OF THE HUMAN EGF RECEPTOR 3.REF PROC.NATL.ACAD.SCI.USA V. 106 21608 2009REFN ISSN 0027-8424PMID 20007378DOI 10.1073/PNAS.0912101106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2rbl TNC high resolution design of a protein loop 2.1Å AUTH X.HU,H.WANG,H.KE,B.KUHLMANTITL HIGH-RESOLUTION DESIGN OF A PROTEIN LOOP.REF PROC.NATL.ACAD.SCI.USA V. 104 17668 2007REFN ISSN 0027-8424PMID 17971437DOI 10.1073/PNAS.0707977104 Variant Set Distributions Mapped Variants
General Structure Information 3oai MPZ crystal structure of the extra-cellular domain of human myelin protein zero 2.1Å AUTH Z.LIU,Y.WANG,R.S.YEDIDI,J.S.BRUNZELLE,I.A.KOVARI,J.SOHI,AUTH 2 J.KAMHOLZ,L.C.KOVARITITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMANTITL 2 MYELIN PROTEIN ZERO.REF PROTEINS V. 80 307 2012REFN ISSN 0887-3585PMID 21971831DOI 10.1002/PROT.23164 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nmz APC crytal structure of apc complexed with asef 3.01Å AUTH Z.ZHANG,L.CHEN,L.GAO,K.LIN,G.WUTITL CRYSTAL STRUCTURE OF APC COMPLEXED WITH ASEFREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1c25 CDC25A human cdc25a catalytic domain 2.3Å AUTH E.B.FAUMAN,J.P.COGSWELL,B.LOVEJOY,W.J.ROCQUE,AUTH 2 W.HOLMES,V.G.MONTANA,H.PIWNICA-WORMS,M.J.RINK,AUTH 3 M.A.SAPERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THETITL 2 HUMAN CELL CYCLE CONTROL PHOSPHATASE, CDC25A.REF CELL(CAMBRIDGE,MASS.) V. 93 617 1998REFN ISSN 0092-8674PMID 9604936DOI 10.1016/S0092-8674(00)81190-3 Variant Set Distributions Mapped Variants
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r83 SYT1 crystal structure analysis of human synaptotagmin 1 c2a-c2b 2.7Å AUTH K.L.FUSON,M.MONTES,J.J.ROBERT,R.B.SUTTONTITL STRUCTURE OF HUMAN SYNAPTOTAGMIN 1 C2AB IN THETITL 2 ABSENCE OF CA2+ REVEALS A NOVEL DOMAIN ASSOCIATION.REF BIOCHEMISTRY V. 46 13041 2007REFN ISSN 0006-2960PMID 17956130DOI 10.1021/BI701651K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3jxf PTPRZ1 ca-like domain of human ptprz 2.0Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants