General Structure Information
| PDB ID | 3kex |
| HGNC Gene Label(s) | ERBB3 |
| Structure Name | crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (her3) |
| Resolution | 2.8Å |
| Reference | AUTH N.JURA,Y.SHAN,X.CAO,D.E.SHAW,J.KURIYANTITL STRUCTURAL ANALYSIS OF THE CATALYTICALLY INACTIVETITL 2 KINASE DOMAIN OF THE HUMAN EGF RECEPTOR 3.REF PROC.NATL.ACAD.SCI.USA V. 106 21608 2009REFN ISSN 0027-8424PMID 20007378DOI 10.1073/PNAS.0912101106 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 292 |
| Number Of SNVs | 56 |
| Number Of Permutations | 50249 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.105 |
| p-value | 0.018 |
COSMIC
| Number Of Residues | 292 |
| Number Of SNVs | 5 |
| Number Of Permutations | 699 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.1 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.094 |
| p-value | 0.962 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
