General Structure Information
| PDB ID | 2df3 |
| HGNC Gene Label(s) | SIGLEC7 |
| Structure Name | the structure of siglec-7 in complex with alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl |
| Resolution | 1.9Å |
| Reference | AUTH H.ATTRILL,H.TAKAZAWA,S.WITT,S.KELM,R.ISECKE,R.BROSSMER,AUTH 2 T.ANDO,H.ISHIDA,M.KISO,P.R.CROCKER,D.M.F.VAN AALTENTITL THE STRUCTURE OF SIGLEC-7 IN COMPLEX WITH SIALOSIDES: LEADSTITL 2 FOR RATIONAL STRUCTURE-BASED INHIBITOR DESIGNREF BIOCHEM.J. V. 397 271 2006REFN ISSN 0264-6021PMID 16623661DOI 10.1042/BJ20060103 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 114 |
| Number Of SNVs | 30 |
| Number Of Permutations | 2853 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.069 |
| p-value | 0.943 |
COSMIC
| Number Of Residues | 114 |
| Number Of SNVs | 5 |
| Number Of Permutations | 190 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.2 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 30 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | -0.108 |
| p-value | 0.547 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
