3HD6.A | RHCG – ASTRID

3HD6.A | RHCG

General Structure Information

PDB ID	3hd6
HGNC Gene Label(s)	RHCG
Structure Name	crystal structure of the human rhesus glycoprotein rhcg
Resolution	2.1Å
Reference	AUTH F.GRUSWITZ,S.CHAUDHARY,J.D.HO,A.SCHLESSINGER,B.PEZESHKI,AUTH 2 C.M.HO,A.SALI,C.M.WESTHOFF,R.M.STROUDTITL FUNCTION OF HUMAN RH BASED ON STRUCTURE OF RHCG AT 2.1 A.REF PROC.NATL.ACAD.SCI.USA V. 107 9638 2010REFN ISSN 0027-8424PMID 20457942DOI 10.1073/PNAS.1003587107

Variant Set Distributions

ExAC Variants

Number Of Residues	402
Number Of SNVs	116
Number Of Permutations	22580
Optimal Distance Threshold	8.0
K Statistic	0.024
p-value	0.945

COSMIC

Number Of Residues	402
Number Of SNVs	3
Number Of Permutations	76
Optimal Distance Threshold	16.0
K Statistic	0.667
p-value	0.135

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	116
Number Of COSMIC SNVs	3
Optimal Distance Threshold	22.0
K Statistic	0.652
p-value	0.178

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:90039772		A>T	A:2	(31.66, 45.37, 20.25)
15:90039767		W>C	A:3	(29.94, 46.81, 16.21)
15:90039762		T>I	A:5	(23.60, 44.12, 21.51)
15:90039759		N>S	A:6	(22.81, 39.08, 22.17)
15:90039753	rs139103543	R>L	A:8	(19.82, 33.97, 25.04)
15:90039741	rs375054718	P>R	A:12	(21.08, 36.41, 32.38)
15:90039738		L>H	A:13	(25.61, 35.85, 34.35)
15:90039712		M>V	A:22	(22.28, 39.84, 47.51)
15:90039706		I>V	A:24	(24.76, 34.29, 50.24)
15:90039703		L>I	A:25	(25.40, 38.54, 51.80)
15:90039697		G>R	A:27	(21.87, 35.09, 55.65)
15:90039687	rs181242584	V>A	A:30	(20.00, 40.29, 57.36)
15:90039688	COSM1375341	V>L	A:30	(20.00, 40.29, 57.36)
15:90039674		F>L	A:34	(12.28, 38.79, 66.64)
15:90039600		R>L	A:59	(10.38, 56.35, 60.00)
15:90030201		H>L	A:67	(9.40, 52.76, 47.11)
15:90030194	rs531227683	M>I	A:69	(10.11, 59.91, 44.56)
15:90030190		F>V	A:71	(10.76, 52.24, 41.88)
15:90030166		T>A	A:79	(9.54, 58.33, 29.72)
15:90030148		G>R	A:85	(10.58, 54.02, 27.68)
15:90030138	COSM3988201	A>V	A:88	(13.53, 54.16, 31.39)
15:90030127		N>D	A:92	(14.74, 52.80, 37.22)
15:90030120		L>P	A:94	(16.70, 46.20, 36.95)
15:90030117		L>W	A:95	(18.70, 50.21, 38.85)
15:90030111		A>V	A:97	(15.76, 46.17, 42.67)
15:90030112		A>S	A:97	(15.76, 46.17, 42.67)
15:90030106		G>S	A:99	(19.96, 48.39, 45.14)
15:90030103		I>F	A:100	(16.83, 48.21, 47.32)
15:90030083		M>I	A:106	(27.18, 48.71, 51.89)
15:90030078		G>D	A:108	(24.72, 48.26, 57.35)
15:90030079	rs553520502	G>S	A:108	(24.72, 48.26, 57.35)
15:90030069	rs142667714	H>R	A:111	(25.02, 50.97, 60.98)
15:90030060		Q>R	A:114	(26.66, 40.41, 67.72)
15:90030054		R>L	A:116	(27.87, 38.04, 62.77)
15:90030031		N>D	A:124	(17.14, 50.11, 57.21)
15:90026438		A>T	A:128	(17.96, 52.29, 50.54)
15:90026423		A>S	A:133	(18.31, 58.04, 44.21)
15:90026410		V>A	A:137	(20.62, 61.09, 39.49)
15:90026411		V>M	A:137	(20.62, 61.09, 39.49)
15:90026407	rs376426485	A>V	A:138	(23.27, 58.98, 37.25)
15:90026405	rs201248594	F>L	A:139	(19.81, 56.04, 34.21)
15:90026395		V>A	A:142	(24.06, 57.51, 31.02)
15:90026380		S>T	A:147	(23.66, 48.37, 29.12)
15:90026375		I>L	A:149	(25.01, 44.68, 31.93)
15:90026366	rs201569897	L>F	A:152	(23.29, 46.18, 37.23)
15:90026361		I>M	A:153	(28.31, 47.23, 36.80)
15:90026351		F>L	A:157	(31.27, 49.52, 41.66)
15:90026342	rs149304854	T>P	A:160	(29.84, 51.09, 47.68)
15:90026330		V>M	A:164	(31.87, 55.42, 51.97)
15:90023617		M>T	A:182	(25.76, 66.97, 50.03)
15:90023597		A>T	A:189	(25.62, 64.18, 39.39)
15:90023578		V>A	A:195	(30.53, 57.99, 33.95)
15:90023579		V>M	A:195	(30.53, 57.99, 33.95)
15:90023572	rs149510924	R>Q	A:197	(34.34, 62.93, 29.25)
15:90023573	rs200573044	R>W	A:197	(34.34, 62.93, 29.25)
15:90023569	rs150439539	I>T	A:198	(35.00, 58.34, 30.68)
15:90023567	rs140495230	L>F	A:199	(31.12, 56.56, 28.48)
15:90023560		R>Q	A:201	(28.81, 57.39, 22.52)
15:90023557	rs201496699	R>H	A:202	(34.14, 60.52, 17.83)
15:90023558	rs17807723	R>C	A:202	(34.14, 60.52, 17.83)
15:90023530		Q>R	A:211	(18.59, 63.12, 22.08)
15:90023526	rs146278239	N>K	A:212	(13.58, 63.57, 20.74)
15:90023522		V>M	A:214	(6.75, 62.53, 21.28)
15:90023514		Q>H	A:216	(2.64, 60.89, 23.12)
15:90023498	COSM1749366	M>V	A:222	(4.48, 65.60, 33.74)
15:90022707		L>R	A:228	(9.35, 63.69, 42.02)
15:90022700		M>I	A:230	(3.31, 65.63, 44.76)
15:90022671		S>F	A:240	(14.26, 64.57, 60.12)
15:90022647		R>Q	A:248	(11.38, 73.27, 60.45)
15:90022642	COSM292331	A>T	A:250	(8.04, 69.92, 54.63)
15:90022627		C>G	A:255	(7.64, 76.75, 49.71)
15:90022609		V>M	A:261	(7.02, 76.44, 39.18)
15:90022605	rs377471544	L>P	A:262	(6.26, 80.78, 39.30)
15:90022599		S>L	A:264	(10.99, 77.81, 35.77)
15:90022597		V>L	A:265	(7.49, 79.25, 33.75)
15:90022594		A>T	A:266	(9.59, 82.69, 33.47)
15:90022587		S>Y	A:268	(11.07, 79.02, 29.55)
15:90022575		H>R	A:272	(10.87, 80.72, 22.94)
15:90021205	rs200646258	V>M	A:280	(12.64, 70.02, 29.35)
15:90021199		I>V	A:282	(7.82, 72.34, 33.03)
15:90021184		L>F	A:287	(12.01, 69.25, 40.50)
15:90021181	COSM1493554	A>T	A:288	(15.33, 72.58, 41.90)
15:90021174		G>V	A:290	(14.27, 70.55, 46.39)
15:90021157		A>T	A:296	(18.23, 73.61, 54.81)
15:90021150		E>A	A:298	(16.50, 70.08, 59.03)
15:90021142		L>F	A:301	(13.89, 79.03, 61.77)
15:90021136	rs375061341	P>T	A:303	(9.33, 80.43, 55.27)
15:90021130	rs201220252	G>S	A:305	(13.99, 81.44, 52.14)
15:90021115		G>S	A:310	(13.49, 78.57, 44.41)
15:90021109	COSM1678665	V>I	A:312	(17.45, 81.40, 42.50)
15:90021103	rs139070731	G>S	A:314	(14.80, 78.01, 38.51)
15:90021099	rs150806791	I>T	A:315	(16.32, 81.38, 37.40)
15:90021097	rs199512977	I>V	A:316	(20.16, 78.71, 38.04)
15:90021081	rs537975718	F>S	A:321	(18.11, 72.36, 31.12)
15:90021078	rs141542346	V>A	A:322	(19.21, 77.02, 27.47)
15:90020884	rs199639414	P>A	A:326	(24.77, 73.24, 25.24)
15:90020871	rs531311212	S>F	A:330	(30.33, 71.51, 22.83)
15:90020868	rs200991324	R>Q	A:331	(34.09, 74.68, 24.88)
15:90020855	rs545843212	Q>H	A:335	(27.42, 63.27, 25.99)
15:90020848	rs186987731	C>G	A:338	(18.34, 64.28, 31.68)
15:90020842	rs371403263 COSM416774	I>V	A:340	(21.84, 65.51, 35.83)
15:90020829		H>R	A:344	(19.86, 66.43, 40.35)
15:90020830		H>Y	A:344	(19.86, 66.43, 40.35)
15:90020826		G>D	A:345	(24.17, 69.65, 40.72)
15:90020823		I>T	A:346	(24.28, 73.51, 39.87)
15:90020811		I>T	A:350	(23.15, 75.85, 45.59)
15:90020806	rs139788541	G>S	A:352	(25.28, 72.97, 50.51)
15:90020800	rs145983648	V>M	A:354	(22.43, 77.18, 51.75)
15:90020784	rs368487303 COSM197766	A>V	A:359	(24.54, 76.15, 60.09)
15:90020390		A>G	A:387	(28.18, 77.36, 64.32)
15:90020391	rs112948665	A>T	A:387	(28.18, 77.36, 64.32)
15:90020382		Q>E	A:390	(28.56, 72.42, 61.67)
15:90020367		I>V	A:395	(31.94, 73.36, 53.02)
15:90020352		V>L	A:400	(34.35, 64.81, 50.47)
15:90020338		M>I	A:404	(34.15, 60.11, 46.69)
15:90020339		M>T	A:404	(34.15, 60.11, 46.69)
15:90020330		M>T	A:407	(37.96, 59.61, 42.90)
15:90020319		I>L	A:411	(37.21, 53.80, 38.97)
15:90020057		L>F	A:414	(37.69, 53.39, 33.06)
15:90020039		F>I	A:420	(33.97, 43.30, 27.79)
15:90020030		Q>K	A:423	(28.08, 48.75, 24.97)
15:90020013		N>K	A:428	(21.82, 52.17, 17.59)
15:90019999		A>V	A:433	(14.96, 47.67, 19.95)
15:90019996		V>A	A:434	(18.70, 47.32, 21.22)
15:90016093		M>T	A:438	(9.25, 46.32, 20.05)
15:90016078	rs143601658	S>N	A:443	(5.33, 44.88, 14.49)

3HD6.A | RHCG.

3HD6.A | RHCG

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants