Assessment of Structural Intolerance and Durability
General Structure Information 1u2h SPEG x-ray structure of the n-terminally truncated human apep-1 0.96Å AUTH B.A.MANJASETTY,F.H.NIESEN,C.SCHEICH,Y.ROSKE,F.GOTZ,AUTH 2 J.BEHLKE,V.SIEVERT,U.HEINEMANN,K.BUSSOWTITL X-RAY STRUCTURE OF ENGINEERED HUMAN AORTICTITL 2 PREFERENTIALLY EXPRESSED PROTEIN-1 (APEG-1)REF BMC STRUCT.BIOL. V. 5 21 2005REFN ESSN 1472-6807PMID 16354304DOI 10.1186/1472-6807-5-21 Variant Set Distributions Mapped Variants
General Structure Information 4bq7 RGMB crystal structure of the rgmb-neo1 complex form 2 6.6Å AUTH C.H.BELL,E.HEALEY,S.VAN ERP,B.BISHOP,C.TANG,R.J.C.GILBERT,AUTH 2 A.R.ARICESCU,R.J.PASTERKAMP,C.SIEBOLDTITL STRUCTURE OF THE REPULSIVE GUIDANCE MOLECULE (RGM)-NEOGENINTITL 2 SIGNALING HUBREF SCIENCE V. 341 77 2013REFN ISSN 0036-8075PMID 23744777DOI 10.1126/SCIENCE.1232322 Variant Set Distributions Mapped Variants
General Structure Information 1wfo SDK2 the eighth fn3 domain of human sidekick-2 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE EIGHTH FN3 DOMAIN OF HUMAN SIDEKICK-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yqg DSG2 solution structure of the first cadherin domain from human desmoglein-2 -1.0Å AUTH R.SANO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST CADHERIN DOMAINTITL 2 FROM HUMAN DESMOGLEIN-2REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l4c DOCK1 structural basis of membrane-targeting by dock180 2.37Å AUTH L.PREMKUMAR,A.A.BOBKOV,M.PATEL,L.JAROSZEWSKI,L.A.BANKSTON,AUTH 2 B.STEC,K.VUORI,J.F.COTE,R.C.LIDDINGTONTITL STRUCTURAL BASIS OF MEMBRANE TARGETING BY THE DOCK180TITL 2 FAMILY OF RHO FAMILY GUANINE EXCHANGE FACTORS (RHO-GEFS).REF J.BIOL.CHEM. V. 285 13211 2010REFN ISSN 0021-9258PMID 20167601DOI 10.1074/JBC.M110.102517 Variant Set Distributions Mapped Variants
General Structure Information 2k9u FLNC solution nmr structure of the filamin-migfilin complex -1.0Å AUTH S.S.ITHYCHANDA,M.DAS,Y.Q.MA,K.DING,X.WANG,S.GUPTA,C.WU,AUTH 2 E.F.PLOW,J.QINTITL MIGFILIN, A MOLECULAR SWITCH IN REGULATION OF INTEGRINTITL 2 ACTIVATION.REF J.BIOL.CHEM. V. 284 4713 2009REFN ISSN 0021-9258PMID 19074766DOI 10.1074/JBC.M807719200 Variant Set Distributions Mapped Variants
General Structure Information 4gxb SNX17 structure of the snx17 atypical ferm domain bound to the npxy motif of p-selectin 1.8Å AUTH R.GHAI,A.BUGARCIC,H.LIU,S.J.NORWOOD,S.SKELDAL,E.J.COULSON,AUTH 2 S.S.LI,R.D.TEASDALE,B.M.COLLINSTITL STRUCTURAL BASIS FOR ENDOSOMAL TRAFFICKING OF DIVERSETITL 2 TRANSMEMBRANE CARGOS BY PX-FERM PROTEINS.REF PROC.NATL.ACAD.SCI.USA V. 110 E643 2013REFN ISSN 0027-8424PMID 23382219DOI 10.1073/PNAS.1216229110 Variant Set Distributions Mapped Variants
General Structure Information 4f7b SCARB2 structure of the lysosomal domain of limp-2 3.0Å AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2k1m MYBPC3 3d nmr structure of domain cc0 of cardiac myosin binding protein c (mybpc) -1.0Å AUTH J.RATTI,M.GAUTEL,M.PFUHLTITL 3D NMR STRUCTURE OF DOMAIN CC0 OF CARDIAC MYOSINTITL 2 BINDING PROTEIN C (MYBPC)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4cnc TPBG crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein) 1.77Å AUTH Y.ZHAO,T.MALINAUSKAS,K.HARLOS,E.Y.JONESTITL STRUCTURAL INSIGHTS INTO THE INHIBITION OF WNT SIGNALING BYTITL 2 CANCER ANTIGEN 5T4/WNT-ACTIVATED INHIBITORY FACTOR 1.REF STRUCTURE V. 22 612 2014REFN ISSN 0969-2126PMID 24582434DOI 10.1016/J.STR.2014.01.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]