General Structure Information
| PDB ID | 4f7b |
| HGNC Gene Label(s) | SCARB2 |
| Structure Name | structure of the lysosomal domain of limp-2 |
| Resolution | 3.0Å |
| Reference | AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 393 |
| Number Of SNVs | 90 |
| Number Of Permutations | 44413 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.081 |
| p-value | 0.696 |
COSMIC
| Number Of Residues | 393 |
| Number Of SNVs | 3 |
| Number Of Permutations | 162 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.313 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 90 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.288 |
| p-value | 0.956 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
