Assessment of Structural Intolerance and Durability
General Structure Information 2×29 TNFSF9 crystal structure of human4-1bb ligand ectodomain 2.3Å AUTH E.Y.WON,K.CHA,J.S.BYUN,D.U.KIM,S.SHIN,B.AHN,Y.H.KIM,AUTH 2 A.J.RICE,T.WALZ,B.S.KWON,H.S.CHOTITL THE STRUCTURE OF THE TRIMER OF HUMAN 4-1BB LIGANDTITL 2 IS UNIQUE AMONG MEMBERS OF THE TUMOR NECROSISTITL 3 FACTOR SUPERFAMILY.REF J.BIOL.CHEM. V. 285 9202 2010REFN ISSN 0021-9258PMID 20032458DOI 10.1074/JBC.M109.084442 Variant Set Distributions Mapped Variants
General Structure Information 2xyn ABL2 human abl2 in complex with aurora kinase inhibitor vx-680 2.81Å AUTH E.SALAH,E.UGOCHUKWU,A.J.BARR,F.VON DELFT,S.KNAPP,AUTH 2 J.M.ELKINSTITL CRYSTAL STRUCTURES OF ABL-RELATED GENE (ABL2) INTITL 2 COMPLEX WITH IMATINIB, TOZASERTIB (VX-680), AND ATITL 3 TYPE I INHIBITOR OF THE TRIAZOLE CARBOTHIOAMIDETITL 4 CLASS.REF J.MED.CHEM. V. 54 2359 2011REFN ISSN 0022-2623PMID 21417343DOI 10.1021/JM101506N Variant […]
General Structure Information 1yo8 THBS2 structure of the c-terminal domain of human thrombospondin-2 2.6Å AUTH C.B.CARLSON,D.A.BERNSTEIN,D.S.ANNIS,T.M.MISENHEIMER,AUTH 2 B.L.HANNAH,D.F.MOSHER,J.L.KECKTITL STRUCTURE OF THE CALCIUM-RICH SIGNATURE DOMAIN OF HUMANTITL 2 THROMBOSPONDIN-2REF NAT.STRUCT.MOL.BIOL. V. 12 910 2005REFN ISSN 1545-9993PMID 16186819DOI 10.1038/NSMB997 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rpm PTPRM human receptor protein tyrosine phosphatase mu, domain 1 2.3Å AUTH K.M.HOFFMANN,N.K.TONKS,D.BARFORDTITL THE CRYSTAL STRUCTURE OF DOMAIN 1 OF RECEPTORTITL 2 PROTEIN-TYROSINE PHOSPHATASE MU.REF J.BIOL.CHEM. V. 272 27505 1997REFN ISSN 0021-9258PMID 9346878DOI 10.1074/JBC.272.44.27505 Variant Set Distributions Mapped Variants
General Structure Information 3k72 ITGAX structure of integrin alphax beta2 3.7Å AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rbl TNC high resolution design of a protein loop 2.1Å AUTH X.HU,H.WANG,H.KE,B.KUHLMANTITL HIGH-RESOLUTION DESIGN OF A PROTEIN LOOP.REF PROC.NATL.ACAD.SCI.USA V. 104 17668 2007REFN ISSN 0027-8424PMID 17971437DOI 10.1073/PNAS.0707977104 Variant Set Distributions Mapped Variants
General Structure Information 3oai MPZ crystal structure of the extra-cellular domain of human myelin protein zero 2.1Å AUTH Z.LIU,Y.WANG,R.S.YEDIDI,J.S.BRUNZELLE,I.A.KOVARI,J.SOHI,AUTH 2 J.KAMHOLZ,L.C.KOVARITITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMANTITL 2 MYELIN PROTEIN ZERO.REF PROTEINS V. 80 307 2012REFN ISSN 0887-3585PMID 21971831DOI 10.1002/PROT.23164 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jxf PTPRZ1 ca-like domain of human ptprz 2.0Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants