General Structure Information
| PDB ID | 2xyn |
| HGNC Gene Label(s) | ABL2 |
| Structure Name | human abl2 in complex with aurora kinase inhibitor vx-680 |
| Resolution | 2.81Å |
| Reference | AUTH E.SALAH,E.UGOCHUKWU,A.J.BARR,F.VON DELFT,S.KNAPP,AUTH 2 J.M.ELKINSTITL CRYSTAL STRUCTURES OF ABL-RELATED GENE (ABL2) INTITL 2 COMPLEX WITH IMATINIB, TOZASERTIB (VX-680), AND ATITL 3 TYPE I INHIBITOR OF THE TRIAZOLE CARBOTHIOAMIDETITL 4 CLASS.REF J.MED.CHEM. V. 54 2359 2011REFN ISSN 0022-2623PMID 21417343DOI 10.1021/JM101506N |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 264 |
| Number Of SNVs | 37 |
| Number Of Permutations | 19099 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.083 |
| p-value | 0.165 |
COSMIC
| Number Of Residues | 264 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1463 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.167 |
| p-value | 0.354 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.351 |
| p-value | 0.446 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
