Assessment of Structural Intolerance and Durability
General Structure Information 2xqn ENAH complex of the 2nd and 3rd lim domains of tes with the evh1 domain of mena and the n-terminal domain of actin-like protein arp7a 2.62Å AUTH B.BOEDA,P.P.KNOWLES,D.C.BRIGGS,J.MURRAY-RUST,E.SORIANO,AUTH 2 B.K.GARVALOV,N.Q.MCDONALD,M.WAYTITL MOLECULAR RECOGNITION OF THE TES LIM2-3 DOMAINS BY THETITL 2 ACTIN-RELATED PROTEIN ARP7A.REF J.BIOL.CHEM. V. 286 11543 2011REFN ISSN 0021-9258PMID 21278383DOI […]
General Structure Information 1va9 DSCAML1 solution structure of the second fniii domain of dscaml1 protein -1.0Å AUTH X.-R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FNIII DOMAIN OFTITL 2 DSCAML1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t6g SH2D3C structure of the complex between nsp3 (shep1) and p130cas 2.5Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Mapped Variants
General Structure Information 4k6j WAPAL human cohesin inhibitor wapl 2.62Å AUTH Z.OUYANG,G.ZHENG,J.SONG,D.M.BOREK,Z.OTWINOWSKI,AUTH 2 C.A.BRAUTIGAM,D.R.TOMCHICK,S.RANKIN,H.YUTITL STRUCTURE OF THE HUMAN COHESIN INHIBITOR WAPL.REF PROC.NATL.ACAD.SCI.USA V. 110 11355 2013REFN ISSN 0027-8424PMID 23776203DOI 10.1073/PNAS.1304594110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bkf EFNB3 crystal structure of the human epha4 ectodomain in complex with human ephrinb3 4.65Å AUTH E.SEIRADAKE,A.SCHAUPP,D.DEL TORO RUIZ,R.KAUFMANN,AUTH 2 N.MITAKIDIS,K.HARLOS,A.R.ARICESCU,R.KLEIN,E.Y.JONESTITL STRUCTURALLY ENCODED INTRACLASS DIFFERENCES IN EPHATITL 2 CLUSTERS DRIVE DISTINCT CELL RESPONSESREF NAT.STRUCT.MOL.BIOL. V. 20 958 2013REFN ISSN 1545-9993PMID 23812375DOI 10.1038/NSMB.2617 Variant Set Distributions Mapped Variants
General Structure Information 4gn1 RAPH1 crystal structure of the ra and ph domains of lamellipodin 2.4Å AUTH Y.C.CHANG,H.ZHANG,M.L.BRENNAN,J.WUTITL CRYSTAL STRUCTURE OF LAMELLIPODIN IMPLICATES DIVERSETITL 2 FUNCTIONS IN ACTIN POLYMERIZATION AND RAS SIGNALING.REF PROTEIN CELL V. 4 211 2013REFN ISSN 1674-800XPMID 23483482DOI 10.1007/S13238-013-2082-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2l6k TENC1 solution structure of a nonphosphorylated peptide recognizing domain -1.0Å AUTH K.DAI,S.LIAO,J.ZHANG,X.ZHANG,X.TUTITL SOLUTION STRUCTURE OF TENSIN2 SH2 DOMAIN AND ITSTITL 2 PHOSPHOTYROSINE-INDEPENDENT INTERACTION WITH DLC-1REF PLOS ONE V. 6 21965 2011REFN ESSN 1932-6203PMID 21765928DOI 10.1371/JOURNAL.PONE.0021965 Variant Set Distributions Mapped Variants
General Structure Information 1wfn SDK2 the fourth fn3 domain of human sidekick-2 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE FOURTH FN3 DOMAIN OF HUMAN SIDEKICK-2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wf5 SDK2 solution structure of the first fn3 domain of sidekick-2 protein -1.0Å AUTH X.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST FN3 DOMAIN OFTITL 2 SIDEKICK-2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3n1q CDON crystal structure of dhhn bound to cdofn3 2.89Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants