Assessment of Structural Intolerance and Durability
General Structure Information 3rrq PDCD1 crystal structure of the extracellular domain of human pd-1 2.1Å AUTH E.LAZAR-MOLNAR,U.A.RAMAGOPAL,S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN PD-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3t6p BIRC2 iap antagonist-induced conformational change in ciap1 promotes e3 ligase activation via dimerization 1.9Å AUTH E.C.DUEBER,A.J.SCHOEFFLER,A.LINGEL,J.M.ELLIOTT,A.V.FEDOROVA,AUTH 2 A.M.GIANNETTI,K.ZOBEL,B.MAURER,E.VARFOLOMEEV,P.WU,AUTH 3 H.J.WALLWEBER,S.G.HYMOWITZ,K.DESHAYES,D.VUCIC,AUTH 4 W.J.FAIRBROTHERTITL ANTAGONISTS INDUCE A CONFORMATIONAL CHANGE IN CIAP1 THATTITL 2 PROMOTES AUTOUBIQUITINATION.REF SCIENCE V. 334 376 2011REFN ISSN 0036-8075PMID 22021857DOI 10.1126/SCIENCE.1207862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4k81 GRB14 crystal structure of the grb14 ra and ph domains in complex with gtp- loaded h-ras 2.4Å AUTH R.QAMRA,S.R.HUBBARDTITL STRUCTURAL BASIS FOR THE INTERACTION OF THE ADAPTOR PROTEINTITL 2 GRB14 WITH ACTIVATED RAS.REF PLOS ONE V. 8 72473 2013REFN ESSN 1932-6203PMID 23967305DOI 10.1371/JOURNAL.PONE.0072473 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2odt ITPK1 structure of human inositol 1,3,4-trisphosphate 5/6-kinase 2.01Å AUTH R.D.BUSAM,C.ARROWSMITH,H.BERGLUND,R.COLLINS,AUTH 2 A.EDWARDS,U.B.ERICSSON,S.FLODIN,A.FLORES,AUTH 3 M.HAMMARSTROM,S.L.HOLMBERG,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 D.OGG,J.SAGEMARK,M.SUNDSTROM,J.UPPENBERG,AUTH 6 S.VAN DEN BERG,J.WEIGELT,C.PERSSON,A.G.THORSELL,AUTH 7 B.M.HALLBERGTITL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATETITL 2 5/6-KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4lp5 AGER crystal structure of the full-length human rage extracellular domain (vc1c2 fragment) 3.8Å AUTH L.YATIME,G.R.ANDERSENTITL STRUCTURAL INSIGHTS INTO THE OLIGOMERIZATION MODE OF THETITL 2 HUMAN RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS.REF FEBS J. V. 280 6556 2013REFN ISSN 1742-464XPMID 24119142DOI 10.1111/FEBS.12556 Variant Set Distributions Mapped Variants
General Structure Information 4b8z TSTA3 crystal structure of human gdp-l-fucose synthase with bound nadp and gdp, rhombohedral crystal form 2.75Å AUTH M.VOLLMAR,T.KROJER,N.SHAFQAT,A.ROJKOVA,G.BUNKOCZI,W.W.YUE,AUTH 2 K.KAVANAGH,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,C.BOUNTRA,AUTH 3 A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GDP-L-FUCOSE SYNTHASE WITH BOUNDTITL 2 NADP AND GDP, RHOMBOHEDRAL CRYSTAL FORMREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rn9 COX17 solution structure of human apocox17 -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,A.JANICKA,AUTH 2 M.MARTINELLI,H.KOZLOWSKI,P.PALUMAATITL A STRUCTURAL-DYNAMICAL CHARACTERIZATION OF HUMANTITL 2 COX17REF J.BIOL.CHEM. V. 283 7912 2008REFN ISSN 0021-9258PMID 18093982DOI 10.1074/JBC.M708016200 Variant Set Distributions Mapped Variants
General Structure Information 3twj ROCK1 rho-associated protein kinase 1 (rock 1) in complex with rki1447 2.9Å AUTH R.A.PATEL,K.D.FORINASH,R.PIREDDU,Y.SUN,N.SUN,M.P.MARTIN,AUTH 2 E.SCHONBRUNN,N.J.LAWRENCE,S.M.SEBTITITL RKI-1447 IS A POTENT INHIBITOR OF THE RHO-ASSOCIATED ROCKTITL 2 KINASES WITH ANTI-INVASIVE AND ANTITUMOR ACTIVITIES INTITL 3 BREAST CANCER.REF CANCER RES. V. 72 5025 2012REFN ISSN 0008-5472PMID 22846914DOI 10.1158/0008-5472.CAN-12-0954 Variant Set Distributions Ripley’s K […]
General Structure Information 1gxe MYBPC3 central domain of cardiac myosin binding protein c -1.0Å AUTH S.IDOWU,M.GAUTEL,S.PERKINS,M.PFUHLTITL STRUCTURE, STABILITY AND DYNAMICS OF THE CENTRALTITL 2 DOMAIN OF CARDIAC MYOSIN BINDING PROTEIN CTITL 3 (MYBP-C): IMPLICATIONS FOR MULTIDOMAIN ASSEMBLYTITL 4 AND CAUSES FOR CARDIOMYOPATHYREF J.MOL.BIOL. V. 329 745 2003REFN ISSN 0022-2836PMID 12787675DOI 10.1016/S0022-2836(03)00425-X Variant Set Distributions Ripley’s […]
General Structure Information 3gc9 MAPK11 the structure of p38beta c119s, c162s in complex with a dihydroquinazolinone inhibitor 2.05Å AUTH S.B.PATEL,P.M.CAMERON,S.J.OKEEFE,B.FRANTZ-WATTLEY,AUTH 2 J.THOMPSON,E.A.ONEILL,T.TENNIS,L.LIU,J.W.BECKER,G.SCAPINTITL THE THREE-DIMENSIONAL STRUCTURE OF MAP KINASE P38BETA:TITL 2 DIFFERENT FEATURES OF THE ATP-BINDING SITE IN P38BETATITL 3 COMPARED WITH P38ALPHA.REF ACTA CRYSTALLOGR.,SECT.D V. 65 777 2009REFN ISSN 0907-4449PMID 19622861DOI 10.1107/S090744490901600X Variant Set Distributions […]