Assessment of Structural Intolerance and Durability
General Structure Information 3g2f BMPR2 crystal structure of the kinase domain of bone morphogenetic protein receptor type ii (bmpr2) at 2.35 a resolution 2.35Å TITL CRYSTAL STRUCTURE OF THE BMPR2 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4eku PTK2B crystal structure of ferm domain of proline-rich tyrosine kinase 2 3.25Å AUTH B.SAVARIMUTHU,R.LI,Y.WANGTITL CRYSTAL STRUCTURE OF THE FERM DOMAIN OF PROLINE-RICHTITL 2 TYROSINE KINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4iir PRPF4B crystal structure of amppnp-bound human prpf4b kinase domain 2.0Å AUTH Q.GAO,I.MECHIN,N.KOTHARI,Z.GUO,G.DENG,K.HAAS,J.MCMANUS,AUTH 2 D.HOFFMANN,A.WANG,D.WIEDERSCHAIN,J.ROCNIK,W.CZECHTIZKY,AUTH 3 X.CHEN,L.MCLEAN,H.ARLT,D.HARPER,F.LIU,T.MAJID,V.PATEL,AUTH 4 C.LENGAUER,C.GARCIA-ECHEVERRIA,B.ZHANG,H.CHENG,M.DORSCH,AUTH 5 S.M.HUANGTITL EVALUATION OF CANCER DEPENDENCE AND DRUGGABILITY OF PRP4TITL 2 KINASE USING CELLULAR, BIOCHEMICAL, AND STRUCTURALTITL 3 APPROACHES.REF J.BIOL.CHEM. V. 288 30125 2013REFN ISSN 0021-9258PMID 24003220DOI 10.1074/JBC.M113.473348 Variant Set Distributions Ripley’s K […]
General Structure Information 2q5a PIN1 human pin1 bound to l-peptide 1.5Å AUTH Y.ZHANG,S.DAUM,D.WILDEMANN,X.Z.ZHOU,M.A.VERDECIA,M.E.BOWMAN,AUTH 2 C.LUCKE,T.HUNTER,K.P.LU,G.FISCHER,J.P.NOELTITL STRUCTURAL BASIS FOR HIGH-AFFINITY PEPTIDE INHIBITION OFTITL 2 HUMAN PIN1.REF ACS CHEM.BIOL. V. 2 320 2007REFN ISSN 1554-8929PMID 17518432DOI 10.1021/CB7000044 Variant Set Distributions Mapped Variants
General Structure Information 2yqg DSG2 solution structure of the first cadherin domain from human desmoglein-2 -1.0Å AUTH R.SANO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST CADHERIN DOMAINTITL 2 FROM HUMAN DESMOGLEIN-2REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dbr NAE1 structural dissection of a gating mechanism preventing misactivation of ubiquitin by nedd8s e1 (appbp1- uba3arg190gln-nedd8ala72arg) 3.05Å AUTH J.SOUPHRON,M.B.WADDELL,A.PAYDAR,Z.TOKGOZ-GROMLEY,AUTH 2 M.F.ROUSSEL,B.A.SCHULMANTITL STRUCTURAL DISSECTION OF A GATING MECHANISMTITL 2 PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8STITL 3 E1.REF BIOCHEMISTRY V. 47 8961 2008REFN ISSN 0006-2960PMID 18652489DOI 10.1021/BI800604C Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2yw5 BRD3 solution structure of the bromodomain from human bromodomain containing protein 3 -1.0Å AUTH M.FURUE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BROMODOMAIN FROM HUMANTITL 2 BROMODOMAIN CONTAINING PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1upt GOLGA4 structure of a complex of the golgin-245 grip domain with arl1 1.7Å AUTH B.PANIC,O.PERISIC,D.B.VEPRINTSEV,R.L.WILLIAMS,AUTH 2 S.MUNROTITL STRUCTURAL BASIS FOR ARL1-DEPENDENT TARGETING OFTITL 2 HOMODIMERIC GRIP DOMAINS TO THE GOLGI APPARATUSREF MOL.CELL V. 12 863 2003REFN ISSN 1097-2765PMID 14580338DOI 10.1016/S1097-2765(03)00356-3 Variant Set Distributions Mapped Variants
General Structure Information 2v7c NR1D2 crystal structure of rev-erb beta 2.4Å AUTH E.-J.WOO,D.G.JEONG,M.-Y.LIM,S.J.KIM,K.-J.KIM,AUTH 2 S.-M.YOON,B.-C.PARK,S.E.RYUTITL STRUCTURAL INSIGHT INTO THE CONSTITUTIVETITL 2 REPRESSION FUNCTION OF THE NUCLEAR RECEPTORTITL 3 REV-ERBBETAREF J.MOL.BIOL. V. 373 735 2007REFN ISSN 0022-2836PMID 17870090DOI 10.1016/J.JMB.2007.08.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ldj CUL1 structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex 3.0Å AUTH N.ZHENG,B.A.SCHULMAN,L.SONG,J.J.MILLER,P.D.JEFFREY,AUTH 2 P.WANG,C.CHU,D.M.KOEPP,S.J.ELLEDGE,M.PAGANO,AUTH 3 R.C.CONAWAY,J.W.CONAWAY,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF THE CUL1-RBX1-SKP1-F BOXSKP2 SCFTITL 2 UBIQUITIN LIGASE COMPLEX.REF NATURE V. 416 703 2002REFN ISSN 0028-0836PMID 11961546DOI 10.1038/416703A Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants