Assessment of Structural Intolerance and Durability
General Structure Information 2kr0 ADRM1 a proteasome protein -1.0Å AUTH X.CHEN,B.H.LEE,D.FINLEY,K.J.WALTERSTITL STRUCTURE OF PROTEASOME UBIQUITIN RECEPTOR HRPN13 AND ITSTITL 2 ACTIVATION BY THE SCAFFOLDING PROTEIN HRPN2.REF MOL.CELL V. 38 404 2010REFN ISSN 1097-2765PMID 20471946DOI 10.1016/J.MOLCEL.2010.04.019 Variant Set Distributions Mapped Variants
General Structure Information 3kb5 TRIM72 pry-spry domain of human trim72 1.5Å AUTH E.Y.PARK,O.-B.KWON,B.-C.JEONG,J.-S.YI,C.S.LEE,AUTH 2 Y.-G.KO,H.K.SONGTITL CRYSTAL STRUCTURE OF PRY-SPRY DOMAIN OF HUMANTITL 2 TRIM72REF PROTEINS 2009REFN ESSN 1097-0134PMID 19967786DOI 10.1002/PROT.22647 Variant Set Distributions Mapped Variants
General Structure Information 3a6n HIST3H3 the nucleosome containing a testis-specific histone variant, human h3t 2.7Å AUTH H.TACHIWANA,W.KAGAWA,A.OSAKABE,K.KAWAGUCHI,T.SHIGA,AUTH 2 Y.HAYASHI-TAKANAKA,H.KIMURA,H.KURUMIZAKATITL STRUCTURAL BASIS OF INSTABILITY OF THE NUCLEOSOME CONTAININGTITL 2 A TESTIS-SPECIFIC HISTONE VARIANT, HUMAN H3TREF PROC.NATL.ACAD.SCI.USA V. 107 10454 2010REFN ISSN 0027-8424PMID 20498094DOI 10.1073/PNAS.1003064107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1wwc NTRK3 nt3 binding domain of human trkc receptor 1.9Å AUTH M.H.ULTSCH,C.WIESMANN,L.C.SIMMONS,J.HENRICH,M.YANG,D.REILLY,AUTH 2 S.H.BASS,A.M.DE VOSTITL CRYSTAL STRUCTURES OF THE NEUROTROPHIN-BINDING DOMAIN OFTITL 2 TRKA, TRKB AND TRKC.REF J.MOL.BIOL. V. 290 149 1999REFN ISSN 0022-2836PMID 10388563DOI 10.1006/JMBI.1999.2816 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ld6 PWWP2B pwwp domain of human pwwp domain-containing protein 2b 1.7Å AUTH L.DOMBROVSKI,A.DONG,W.TEMPEL,P.LOPPNAU,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,P.J.BROWN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PWWP DOMAIN OF HUMAN PWWPTITL 2 DOMAIN-CONTAINING PROTEIN 2BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ocp DGUOK crystal structure of human deoxyguanosine kinase 2.8Å AUTH K.JOHANSSON,S.RAMASWAMY,C.LJUNGKRANTZ,W.KNECHT,AUTH 2 J.PISKUR,B.MUNCH-PETERSEN,S.ERIKSSON,H.EKLUNDTITL STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITIES OFTITL 2 CELLULAR DEOXYRIBONUCLEOSIDE KINASES.REF NAT.STRUCT.BIOL. V. 8 616 2001REFN ISSN 1072-8368PMID 11427893DOI 10.1038/89661 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yrv UBE2U novel ubiquitin-conjugating enzyme 2.18Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3cfv RBBP7 structural basis of the interaction of rbap46/rbap48 with histone h4 2.6Å AUTH N.V.MURZINA,X.Y.PEI,W.ZHANG,M.SPARKES,AUTH 2 J.VICENTE-GARCIA,J.V.PRATAP,S.H.MCLAUGHLIN,AUTH 3 T.R.BEN-SHAHAR,A.VERREAULT,B.F.LUISI,E.D.LAUETITL STRUCTURAL BASIS FOR THE RECOGNITION OF HISTONE H4TITL 2 BY THE HISTONE-CHAPERONE RBAP46.REF STRUCTURE V. 16 1077 2008REFN ISSN 0969-2126PMID 18571423DOI 10.1016/J.STR.2008.05.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4kng RNF43 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1saw FAHD1 x-ray structure of homo sapiens protein flj36880 2.2Å AUTH B.A.MANJASETTY,F.H.NIESEN,H.DELBRUCK,F.GOTZ,AUTH 2 V.SIEVERT,K.BUSSOW,J.BEHLKE,U.HEINEMANNTITL X-RAY STRUCTURE OF FUMARYLACETOACETATE HYDROLASETITL 2 FAMILY MEMBER HOMO SAPIENS FLJ36880.REF BIOL.CHEM. V. 385 935 2004REFN ISSN 1431-6730PMID 15551868DOI 10.1515/BC.2004.122 Variant Set Distributions Mapped Variants