General Structure Information
| PDB ID | 4kng |
| HGNC Gene Label(s) | RNF43 |
| Structure Name | crystal structure of human lgr5-rspo1-rnf43 |
| Resolution | 2.5Å |
| Reference | AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 148 |
| Number Of SNVs | 34 |
| Number Of Permutations | 12698 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.062 |
| p-value | 0.422 |
COSMIC
| Number Of Residues | 148 |
| Number Of SNVs | 8 |
| Number Of Permutations | 2282 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.214 |
| p-value | 0.061 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.3 |
| p-value | 0.206 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
