2KR0.A | ADRM1

General Structure Information

PDB ID	2kr0
HGNC Gene Label(s)	ADRM1
Structure Name	a proteasome protein
Resolution	-1.0Å
Reference	AUTH X.CHEN,B.H.LEE,D.FINLEY,K.J.WALTERSTITL STRUCTURE OF PROTEASOME UBIQUITIN RECEPTOR HRPN13 AND ITSTITL 2 ACTIVATION BY THE SCAFFOLDING PROTEIN HRPN2.REF MOL.CELL V. 38 404 2010REFN ISSN 1097-2765PMID 20471946DOI 10.1016/J.MOLCEL.2010.04.019

Variant Set Distributions

ExAC Variants

Number Of Residues	407
Number Of SNVs	90
Number Of Permutations	83117
Optimal Distance Threshold	17.0
K Statistic	0.076
p-value	0.09

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
20:60878644		L>P	A:7	(-53.29, -17.49, 18.14)
20:60878649		P>A	A:9	(-52.74, -12.04, 14.27)
20:60878653		S>N	A:10	(-48.29, -13.12, 16.52)
20:60878658	rs376432621	V>L	A:12	(-43.57, -9.26, 12.67)
20:60878659		V>A	A:12	(-43.57, -9.26, 12.67)
20:60878661		P>A	A:13	(-45.77, -6.97, 9.24)
20:60878665		G>D	A:14	(-42.84, -6.11, 6.30)
20:60878682	rs373700307	N>D	A:20	(-35.12, 4.30, 0.67)
20:60878683	rs11544169	N>S	A:20	(-35.12, 4.30, 0.67)
20:60878719		S>F	A:32	(-4.56, 3.65, 1.89)
20:60878769		I>V	A:49	(-24.25, 8.91, 0.97)
20:60878779	rs369612978	T>M	A:52	(-27.81, 10.73, 10.91)
20:60878790	COSM1632387	L>F	A:56	(-26.18, 15.43, 10.66)
20:60878815		R>K	A:64	(-19.44, -5.75, -3.20)
20:60878828		N>K	A:68	(-16.63, -6.75, 6.19)
20:60878829		V>L	A:69	(-18.69, -1.92, 8.10)
20:60879565		C>R	A:88	(-7.23, 10.75, -13.75)
20:60879568		P>S	A:89	(-5.67, 8.70, -17.12)
20:60879584		Y>C	A:94	(-14.26, 10.94, -8.57)
20:60881256		P>S	A:112	(-19.07, -0.98, -15.33)
20:60881260		K>R	A:113	(-22.13, 0.93, -18.59)
20:60881262		T>P	A:114	(-17.57, 5.85, -17.83)
20:60881267	rs202092326	D>E	A:115	(-22.80, 7.01, -18.83)
20:60881280	rs539577971	H>Y	A:120	(-22.93, 7.97, -9.54)
20:60881287		R>Q	A:122	(-25.32, 17.62, -9.67)
20:60881289		K>E	A:123	(-27.79, 11.60, -7.61)
20:60881352		G>S	A:144	(-23.04, 32.53, 21.14)
20:60881723		S>R	A:158	(3.45, 38.78, 19.85)
20:60881736	rs140415181	M>V	A:163	(10.70, 46.44, 28.52)
20:60881766		G>R	A:173	(10.20, 52.82, 3.86)
20:60881775		G>S	A:176	(5.32, 53.86, 0.78)
20:60882444		T>P	A:187	(-22.64, 55.47, -0.83)
20:60882487	rs372346185	P>L	A:201	(-26.05, 63.48, -25.33)
20:60882499		S>F	A:205	(-22.81, 71.61, -26.15)
20:60882653		S>A	A:209	(-16.06, 79.72, -28.44)
20:60882680	COSM3405252	P>S	A:218	(5.79, 75.68, -39.54)
20:60882681	rs193921052 COSM1179094	P>L	A:218	(5.79, 75.68, -39.54)
20:60882690		T>I	A:221	(0.50, 78.75, -46.56)
20:60882702		T>I	A:225	(-3.96, 68.35, -48.05)
20:60882704		R>C	A:226	(-6.85, 70.73, -54.60)
20:60882705	rs549209843	R>H	A:226	(-6.85, 70.73, -54.60)
20:60882713		P>A	A:229	(-10.52, 62.40, -47.66)
20:60882714		P>L	A:229	(-10.52, 62.40, -47.66)
20:60882720	rs373938952	P>L	A:231	(-10.93, 57.95, -43.04)
20:60882723		S>F	A:232	(-7.84, 57.51, -39.51)
20:60882725		A>S	A:233	(-10.77, 53.87, -39.04)
20:60882734		A>T	A:236	(-6.50, 50.22, -31.66)
20:60882743		A>T	A:239	(-8.45, 40.10, -31.20)
20:60882750		S>I	A:241	(-10.81, 34.81, -30.34)
20:60882751		S>R	A:241	(-10.81, 34.81, -30.34)
20:60882758		P>S	A:244	(-1.84, 32.98, -25.72)
20:60882761		A>T	A:245	(1.62, 29.96, -28.05)
20:60882762	rs200789814	A>V	A:245	(1.62, 29.96, -28.05)
20:60882773		G>R	A:249	(7.52, 31.09, -16.73)
20:60882789	rs553787199	T>R	A:254	(10.34, 26.22, -15.94)
20:60882801		P>L	A:258	(-1.34, 25.93, -14.07)
20:60882845		T>A	A:273	(3.96, 17.50, 12.17)
20:60882853		N>K	A:275	(-1.72, 12.42, 11.18)
20:60882863		G>R	A:279	(7.98, 14.90, 5.46)
20:60882864	rs543223102	G>E	A:279	(7.98, 14.90, 5.46)
20:60882867		P>L	A:280	(7.47, 18.51, 7.14)
20:60882875	COSM1566171	G>S	A:283	(7.64, 15.57, -1.11)
20:60882882	rs556646029	Q>P	A:285	(11.95, 13.46, 0.15)
20:60883091		V>M	A:291	(13.03, 9.25, -11.27)
20:60883101		P>L	A:294	(15.38, 0.20, -6.41)
20:60883105		E>D	A:295	(17.76, -1.87, -10.22)
20:60883124		A>T	A:302	(25.35, -0.27, -0.08)
20:60883130		A>T	A:304	(29.62, 3.27, 4.57)
20:60883131	rs199629793	A>V	A:304	(29.62, 3.27, 4.57)
20:60883145		R>C	A:309	(27.35, 12.47, 4.85)
20:60883146	rs373828612	R>H	A:309	(27.35, 12.47, 4.85)
20:60883163		P>S	A:315	(13.51, 11.47, 11.59)
20:60883169	rs202035396	G>R	A:317	(11.41, 5.35, 13.51)
20:60883176	rs578081411	S>L	A:319	(15.83, 1.10, 10.08)
20:60883182		P>L	A:321	(18.21, -1.05, 3.83)
20:60883190		A>T	A:324	(23.40, -4.04, -2.47)
20:60883191	rs45576934	A>V	A:324	(23.40, -4.04, -2.47)
20:60883205		N>D	A:329	(16.30, -8.61, -4.16)
20:60883206		N>S	A:329	(16.30, -8.61, -4.16)
20:60883218		S>L	A:333	(8.04, 1.52, -0.92)
20:60883431		G>D	A:341	(15.06, 11.72, 0.92)
20:60883442	rs150640020	A>T	A:345	(18.81, 16.35, 2.04)
20:60883451		A>S	A:348	(20.57, 19.56, -1.89)
20:60883462		Q>H	A:351	(27.19, 17.54, 2.40)
20:60883479		C>Y	A:357	(32.99, 11.92, -8.22)
20:60883487		G>S	A:360	(31.26, 6.90, -11.44)
20:60883517		N>D	A:370	(29.60, 18.42, -6.81)
20:60883729		K>R	A:379	(15.84, 15.48, -16.57)
20:60883737	rs200530119	Q>E	A:382	(15.40, 10.53, -16.12)
20:60883743		N>D	A:384	(22.88, 8.87, -19.02)
20:60883746		A>T	A:385	(19.33, 5.63, -17.91)
20:60883762	rs73916515	K>T	A:390	(19.96, -0.32, -24.80)
20:60883764		E>K	A:391	(20.27, 4.01, -29.03)
20:60883765		E>A	A:391	(20.27, 4.01, -29.03)
20:60883767	rs370417009	G>S	A:392	(21.64, 0.19, -31.43)
20:60883770		D>N	A:393	(23.63, -3.44, -31.69)
20:60883774		T>M	A:394	(25.18, -0.86, -35.48)
20:60883783	rs36107815	K>R	A:397	(31.40, 1.19, -36.62)
20:60883791	rs140787599	E>K	A:400	(41.62, -5.89, -39.48)
20:60883795	rs368420066	E>G	A:401	(44.43, -5.78, -34.99)
20:60883799		E>D	A:402	(47.77, -5.07, -38.85)
20:60883803	rs199937384	M>V	A:404	(52.68, -1.81, -35.76)
20:60883807		S>N	A:405	(47.07, -1.31, -34.50)