General Structure Information
| PDB ID | 3a6n |
| HGNC Gene Label(s) | HIST3H3 |
| Structure Name | the nucleosome containing a testis-specific histone variant, human h3t |
| Resolution | 2.7Å |
| Reference | AUTH H.TACHIWANA,W.KAGAWA,A.OSAKABE,K.KAWAGUCHI,T.SHIGA,AUTH 2 Y.HAYASHI-TAKANAKA,H.KIMURA,H.KURUMIZAKATITL STRUCTURAL BASIS OF INSTABILITY OF THE NUCLEOSOME CONTAININGTITL 2 A TESTIS-SPECIFIC HISTONE VARIANT, HUMAN H3TREF PROC.NATL.ACAD.SCI.USA V. 107 10454 2010REFN ISSN 0027-8424PMID 20498094DOI 10.1073/PNAS.1003064107 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 97 |
| Number Of SNVs | 43 |
| Number Of Permutations | 5840 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.224 |
| p-value | 0.137 |
COSMIC
| Number Of Residues | 97 |
| Number Of SNVs | 3 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.546 |
| p-value | 0.345 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
