General Structure Information
| PDB ID | 3t6p |
| HGNC Gene Label(s) | BIRC2 |
| Structure Name | iap antagonist-induced conformational change in ciap1 promotes e3 ligase activation via dimerization |
| Resolution | 1.9Å |
| Reference | AUTH E.C.DUEBER,A.J.SCHOEFFLER,A.LINGEL,J.M.ELLIOTT,A.V.FEDOROVA,AUTH 2 A.M.GIANNETTI,K.ZOBEL,B.MAURER,E.VARFOLOMEEV,P.WU,AUTH 3 H.J.WALLWEBER,S.G.HYMOWITZ,K.DESHAYES,D.VUCIC,AUTH 4 W.J.FAIRBROTHERTITL ANTAGONISTS INDUCE A CONFORMATIONAL CHANGE IN CIAP1 THATTITL 2 PROMOTES AUTOUBIQUITINATION.REF SCIENCE V. 334 376 2011REFN ISSN 0036-8075PMID 22021857DOI 10.1126/SCIENCE.1207862 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 329 |
| Number Of SNVs | 69 |
| Number Of Permutations | 11395 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.059 |
| p-value | 0.296 |
COSMIC
| Number Of Residues | 329 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1850 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.467 |
| p-value | 0.293 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.265 |
| p-value | 0.168 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
