4LP5.A | AGER – ASTRID

4LP5.A | AGER

General Structure Information

PDB ID	4lp5
HGNC Gene Label(s)	AGER
Structure Name	crystal structure of the full-length human rage extracellular domain (vc1c2 fragment)
Resolution	3.8Å
Reference	AUTH L.YATIME,G.R.ANDERSENTITL STRUCTURAL INSIGHTS INTO THE OLIGOMERIZATION MODE OF THETITL 2 HUMAN RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS.REF FEBS J. V. 280 6556 2013REFN ISSN 1742-464XPMID 24119142DOI 10.1111/FEBS.12556

Variant Set Distributions

ExAC Variants

Number Of Residues	299
Number Of SNVs	85
Number Of Permutations	60479
Optimal Distance Threshold	41.0
K Statistic	0.466
p-value	0.318

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
6:32151734	rs17846804	A>V	A:28	(64.37, -35.22, -3.08)
6:32151735		A>T	A:28	(64.37, -35.22, -3.08)
6:32151731		R>Q	A:29	(67.18, -29.70, -3.74)
6:32151732	rs144337279	R>W	A:29	(67.18, -29.70, -3.74)
6:32151725		G>D	A:31	(67.10, -28.95, 2.58)
6:32151719	rs199964705	P>L	A:33	(60.98, -30.26, 2.56)
6:32151706		K>N	A:37	(49.82, -39.77, 0.95)
6:32151703	rs201829223	C>W	A:38	(49.16, -42.81, 4.60)
6:32151699		G>R	A:40	(43.77, -44.70, 4.28)
6:32151674	rs139629784	R>Q	A:48	(44.31, -48.96, 13.86)
6:32151517		R>Q	A:57	(69.34, -41.03, 9.60)
6:32151499		V>G	A:63	(59.12, -48.32, 14.34)
6:32151500		V>I	A:63	(59.12, -48.32, 14.34)
6:32151479		G>S	A:70	(62.76, -37.08, 19.96)
6:32151470		D>N	A:73	(60.73, -35.07, 16.55)
6:32151467		S>G	A:74	(64.17, -32.94, 14.01)
6:32151458	rs116828224	R>C	A:77	(57.69, -35.33, 12.57)
6:32151443	rs2070600	G>S	A:82	(49.62, -39.43, 8.68)
6:32151427		P>L	A:87	(62.35, -31.23, 8.01)
6:32151419		G>R	A:90	(69.00, -36.31, 3.47)
6:32151388		Q>L	A:100	(49.68, -50.92, 8.10)
6:32151385		A>V	A:101	(46.45, -48.64, 7.16)
6:32151376		R>K	A:104	(36.10, -46.34, 11.54)
6:32151367		K>R	A:107	(40.08, -50.85, 4.11)
6:32151365		E>K	A:108	(45.32, -53.30, 5.13)
6:32151346	rs17846806	R>Q	A:114	(63.03, -47.09, -4.36)
6:32151343		V>A	A:115	(63.62, -42.08, -1.26)
6:32151341		R>C	A:116	(66.28, -42.93, -5.38)
6:32151159		P>L	A:121	(75.54, -28.30, -8.94)
6:32151156		G>V	A:122	(77.32, -25.30, -9.51)
6:32151154		K>E	A:123	(77.82, -22.32, -13.67)
6:32151147		E>V	A:125	(84.10, -22.84, -13.18)
6:32151141		V>G	A:127	(90.44, -23.95, -14.76)
6:32151112		V>F	A:137	(100.44, -31.69, -30.86)
6:32150978	rs372397484	V>M	A:141	(92.23, -26.99, -23.42)
6:32150967	rs138726985	C>W	A:144	(85.90, -28.97, -15.99)
6:32150969		C>R	A:144	(85.90, -28.97, -15.99)
6:32150947	COSM1162061	P>L	A:151	(74.49, -37.79, -7.84)
6:32150922	rs188057660	L>F	A:159	(83.15, -28.76, -30.92)
6:32150918		G>W	A:161	(77.52, -27.72, -29.78)
6:32150909		L>V	A:164	(83.62, -34.80, -28.16)
6:32150898		N>K	A:167	(88.82, -42.75, -27.54)
6:32150798		V>L	A:171	(89.75, -36.06, -27.94)
6:32150795		S>P	A:172	(91.96, -36.98, -24.42)
6:32150779		T>I	A:177	(85.55, -38.26, -8.66)
6:32150775		R>S	A:178	(88.30, -36.69, -5.96)
6:32150765		E>K	A:182	(82.14, -34.08, 6.95)
6:32150750		T>S	A:187	(83.90, -32.50, -6.49)
6:32150738		E>K	A:191	(92.71, -32.87, -18.27)
6:32150729		V>L	A:194	(92.91, -31.63, -28.48)
6:32150716	rs375056984	R>Q	A:198	(97.98, -29.09, -40.28)
6:32150701		R>H	A:203	(88.21, -18.54, -35.61)
6:32150702		R>C	A:203	(88.21, -18.54, -35.61)
6:32150692	rs373910069	F>S	A:206	(86.25, -26.13, -27.27)
6:32150690		S>P	A:207	(81.63, -26.45, -23.91)
6:32150666	rs562985782	P>S	A:215	(66.37, -36.59, -15.14)
6:32150656		R>Q	A:218	(68.90, -29.82, -18.99)
6:32150657	rs149408505	R>W	A:218	(68.90, -29.82, -18.99)
6:32150649		L>F	A:220	(74.98, -26.51, -15.82)
6:32150648		R>C	A:221	(74.93, -25.72, -20.97)
6:32150636		I>L	A:225	(86.51, -21.73, -24.56)
6:32150629		P>L	A:227	(90.63, -21.13, -28.64)
6:32150626		R>H	A:228	(92.65, -17.74, -32.84)
6:32150627		R>C	A:228	(92.65, -17.74, -32.84)
6:32150455		V>F	A:238	(118.90, -28.89, -45.43)
6:32150446	rs17846799	V>L	A:241	(124.77, -36.32, -50.01)
6:32150443	rs138936868	V>M	A:242	(128.45, -38.12, -48.38)
6:32150439		E>A	A:243	(129.55, -39.66, -52.08)
6:32150436		P>Q	A:244	(131.12, -42.45, -49.05)
6:32150430	rs150282885	G>D	A:246	(130.19, -43.17, -43.44)
6:32150431		G>S	A:246	(130.19, -43.17, -43.44)
6:32150427		G>E	A:247	(132.67, -41.13, -43.02)
6:32150424	rs376859625	A>G	A:248	(135.13, -42.95, -44.91)
6:32150418		A>G	A:250	(140.98, -43.66, -48.50)
6:32150413		G>S	A:252	(142.75, -40.06, -51.36)
6:32150404		V>I	A:255	(134.91, -36.55, -50.23)
6:32150385	rs201178949	V>D	A:261	(117.65, -26.63, -50.77)
6:32150382		P>R	A:262	(113.93, -27.70, -50.68)
6:32150356	rs140930365	W>R	A:271	(129.61, -26.01, -49.02)
6:32150345		D>E	A:274	(132.33, -27.50, -38.11)
6:32150347		D>N	A:274	(132.33, -27.50, -38.11)
6:32150164		G>D	A:275	(133.39, -24.25, -36.16)
6:32150162		V>M	A:276	(135.07, -22.70, -38.70)
6:32150138		P>S	A:284	(126.05, -26.86, -54.93)
6:32150132		L>V	A:286	(132.33, -29.48, -50.90)
6:32150120	rs201866140	E>Q	A:290	(144.01, -35.12, -53.32)
6:32150114		G>R	A:292	(144.07, -35.85, -45.39)
6:32150110	rs201967398	P>L	A:293	(145.01, -35.93, -42.00)
6:32150111		P>S	A:293	(145.01, -35.93, -42.00)
6:32150108		Q>E	A:294	(145.13, -32.33, -43.53)
6:32150096		T>A	A:298	(132.88, -31.75, -38.57)
6:32150065		H>P	A:308	(115.71, -17.05, -40.27)
6:32150056		Q>R	A:311	(118.51, -23.63, -43.07)
6:32150047	rs77170610	R>H	A:314	(123.78, -34.71, -41.83)
6:32150048		R>C	A:314	(123.78, -34.71, -41.83)
6:32150039	rs529074355	S>G	A:317	(131.87, -36.65, -39.76)