General Structure Information
| PDB ID | 3twj |
| HGNC Gene Label(s) | ROCK1 |
| Structure Name | rho-associated protein kinase 1 (rock 1) in complex with rki1447 |
| Resolution | 2.9Å |
| Reference | AUTH R.A.PATEL,K.D.FORINASH,R.PIREDDU,Y.SUN,N.SUN,M.P.MARTIN,AUTH 2 E.SCHONBRUNN,N.J.LAWRENCE,S.M.SEBTITITL RKI-1447 IS A POTENT INHIBITOR OF THE RHO-ASSOCIATED ROCKTITL 2 KINASES WITH ANTI-INVASIVE AND ANTITUMOR ACTIVITIES INTITL 3 BREAST CANCER.REF CANCER RES. V. 72 5025 2012REFN ISSN 0008-5472PMID 22846914DOI 10.1158/0008-5472.CAN-12-0954 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 396 |
| Number Of SNVs | 36 |
| Number Of Permutations | 25557 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.262 |
| p-value | 0.061 |
COSMIC
| Number Of Residues | 396 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2259 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | 0.333 |
| p-value | 0.398 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 36 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | -0.257 |
| p-value | 0.484 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
