Assessment of Structural Intolerance and Durability
General Structure Information 2ly4 TP53 hmgb1-facilitated p53 dna binding occurs via hmg-box/p53 transactivation domain interaction and is regulated by the acidic tail -1.0Å AUTH J.P.ROWELL,K.L.SIMPSON,K.STOTT,M.WATSON,J.O.THOMASTITL HMGB1-FACILITATED P53 DNA BINDING OCCURS VIA HMG-BOX/P53TITL 2 TRANSACTIVATION DOMAIN INTERACTION, REGULATED BY THE ACIDICTITL 3 TAIL.REF STRUCTURE V. 20 2014 2012REFN ISSN 0969-2126PMID 23063560DOI 10.1016/J.STR.2012.09.004 Variant Set Distributions Ripley’s […]
General Structure Information 3ajq FTH1 crystal structure of human h ferritin e140q mutant 1.58Å AUTH T.MASUDA,F.GOTO,T.YOSHIHARA,B.MIKAMITITL THE UNIVERSAL MECHANISM FOR IRON TRANSLOCATION TO THETITL 2 FERROXIDASE SITE IN FERRITIN, WHICH IS MEDIATED BY THE WELLTITL 3 CONSERVED TRANSIT SITEREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 400 94 2010REFN ISSN 0006-291XPMID 20705053DOI 10.1016/J.BBRC.2010.08.017 Variant Set Distributions Mapped Variants
General Structure Information 2xwj C3 crystal structure of complement c3b in complex with factor b 4.0Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4kc3 IL33 cytokine/receptor binary complex 3.27Å AUTH X.LIU,M.HAMMEL,Y.HE,J.A.TAINER,U.S.JENG,L.ZHANG,S.WANG,AUTH 2 X.WANGTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF IL-33 WITH ITSTITL 2 RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 110 14918 2013REFN ISSN 0027-8424PMID 23980170DOI 10.1073/PNAS.1308651110 Variant Set Distributions Mapped Variants
General Structure Information 2coe DNTT solution structure of brct domain of terminal deoxynucleotidyltransferase -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF BRCT DOMAIN OF TERMINALTITL 2 DEOXYNUCLEOTIDYLTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3s5l HLA-DRA crystal structure of cd4 mutant bound to hla-dr1 2.1Å AUTH X.X.WANG,Y.LI,Y.YIN,M.MO,Q.WANG,W.GAO,L.WANG,R.A.MARIUZZATITL AFFINITY MATURATION OF HUMAN CD4 BY YEAST SURFACE DISPLAYTITL 2 AND CRYSTAL STRUCTURE OF A CD4-HLA-DR1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 108 15960 2011REFN ISSN 0027-8424PMID 21900604DOI 10.1073/PNAS.1109438108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3fji FGF1 crystal structure of k12v/c83i/c117v mutant of human acidic fibroblast growth factor 2.55Å AUTH J.LEE,M.BLABERTITL STRUCTURAL BASIS OF CONSERVED CYSTEINE IN THETITL 2 FIBROBLAST GROWTH FACTOR FAMILY: EVIDENCE FOR ATITL 3 VESTIGIAL HALF-CYSTINE.REF J.MOL.BIOL. V. 393 128 2009REFN ISSN 0022-2836PMID 19683004DOI 10.1016/J.JMB.2009.08.007 Variant Set Distributions Mapped Variants
General Structure Information 4jnl PLAU crystal structure of upa in complex with its inhibitor 4- bromobenzylamine at ph 7.4 2.0Å AUTH X.ZHANG,L.JIANG,B.ZHAO,C.YUAN,M.HUANGTITL HALOGEN BONDS IN THE DESIGN OF SERINE PROTEASE INHIBITORSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lwi HRAS solution structure of h-rast35s mutant protein in complex with kobe2601 -1.0Å AUTH F.SHIMA,Y.YOSHIKAWA,M.YE,M.ARAKI,S.MATSUMOTO,J.LIAO,L.HU,AUTH 2 T.SUGIMOTO,Y.IJIRI,A.TAKEDA,Y.NISHIYAMA,C.SATO,S.MURAOKA,AUTH 3 A.TAMURA,T.OSODA,K.I.TSUDA,T.MIYAKAWA,H.FUKUNISHI,J.SHIMADA,AUTH 4 T.KUMASAKA,M.YAMAMOTO,T.KATAOKATITL IN SILICO DISCOVERY OF SMALL-MOLECULE RAS INHIBITORS THATTITL 2 DISPLAY ANTITUMOR ACTIVITY BY BLOCKING THE RAS-EFFECTORTITL 3 INTERACTION.REF PROC.NATL.ACAD.SCI.USA 2013REFN ESSN 1091-6490PMID 23630290DOI 10.1073/PNAS.1217730110 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4mzr TP53 crystal structure of a polypeptide p53 mutant bound to dna 2.9Å AUTH S.EMAMZADAH,L.TROPIA,I.VINCENTI,B.FALQUET,T.D.HALAZONETISTITL REVERSAL OF THE DNA-BINDING-INDUCED LOOP L1 CONFORMATIONALTITL 2 SWITCH IN AN ENGINEERED HUMAN P53 PROTEIN.REF J.MOL.BIOL. V. 426 936 2014REFN ISSN 0022-2836PMID 24374182DOI 10.1016/J.JMB.2013.12.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]